Chapter 22 - Pathogenicity and Histidine Kinases: Approaches Toward the Development of a New Generation of Antibiotics
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Protein histidine kinases: assembly of active sites and their regulation in signaling pathways
2010, Current Opinion in MicrobiologyCitation Excerpt :Defining how these enzymes function is important for understanding the machinery utilized by many organisms to perceive and respond to their worlds. Further interest in PHKs stems from observations that some regulate expression of cell components vital for survival and/or virulence in pathogenic microbes, and so they might be exploited as targets for new antimicrobial drugs [5–8]. Such efforts would benefit from a detailed understanding of PHK biochemistry and their structural/functional organization.
Chemical signaling among bacteria and its inhibition
2003, Chemistry and BiologyNew class of competitive inhibitor of bacterial histidine kinases
2005, Journal of Bacteriology
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