10 - Tracer Experiment Design for Metabolic Fluxes Estimation in Steady and Nonsteady State
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The Development and Enhancement of FRAP as a Key Tool for Investigating Protein Dynamics
2018, Biophysical JournalCitation Excerpt :This approach of linking two systems has been applied to the analysis of non-steady-state tracer experiments at levels of biological organization from single cells (7,57) to human metabolic physiology (68) and pharmaceutical development (69). The above “linking” approach differs from classic methods of estimating fluxes in non-steady states, which employ additional tracers of the same molecule to supply the required information (70) or employ hybrid algebraic and stochastic methods (71). These classic methods consider only tracer dynamics and do not directly account for the impact of the underlying nonlinear dynamics in non-steady state experiments.
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