Cytochrome P450

doi:10.1016/0959-440X(95)80009-3

Current Opinion in Structural Biology

Volume 5, Issue 6, December 1995, Pages 767-774

https://doi.org/10.1016/0959-440X(95)80009-3 Get rights and content

Abstract

Since 1993, three new cytochrome P450 X-ray structures have been determined, giving a total of four known structures. Two of the new structures are in the substrate-free form and one is substrate-bound. These new structures, together with a wealth of mutagenesis studies on various P450s, have provided considerable information on what structural features control substrate specificity in P450s. In addition, some important insights into the catalytic mechanism have been made.

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Cytochrome P450

Abstract

Nature Struct Biol

J Biol Chem

Structure

Annu Rev Pharmacol Toxicol

Biochemistry

J Biol Chem

J Biol Chem

J Mol Graph

J Comput Aided Mol Des

Mol Endocrinol

Biochem Biophys Res Commun

J Biol Chem

X-ray crystallographic structural studies on cytochrome P450cam: factors controlling substrate metabolism

Front Biotransform

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450s

Science

Modeling protein substrate interactions in the heme domain of cytochrome P450BM-3

Acta Crystallogr [D]

Crystal structure and refinement of cytochrome P450terp at 2.3Å resolution

J Mol Biol

Identification and characterization of the two functional domains in cytochrome P450BM-3, a catalytically self-sufficient monooxygenease induced by barbituates in Bacillus megaterium

J Biol Chem

The nitric oxide synthase family of proteins

J Vasc Res

Characterization of Saccharapolyspora erythraea cytochrome P450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase

J Bacteriol

Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in E. coli: influence of the NH2-terminal region on localization in cytosol and membranes

Proc Natl Acad Sci USA

E. coli expression and characterization of cytochromes P450, 2B11, 2B1, and 2B5

Arch Biochem Biophys

Expression of cytochrome P450 3A5 in E. coli: Effects of 5′ modification, purification, spectral characterization, reconstitution conditions, and catalytic activities

Arch Biochem Biophys

Crystallographic refinement of lignin peroxidase at 2Å resolution

J Biol Chem

Crystal structure of the fungal peroxidase from Arthromyces ramosus at 1.9Å resolution

J Mol Biol

X-ray crystallographic structural studies on cytochrome P450_cam: factors controlling substrate metabolism

Crystal structure of hemoprotein domain of P450_BM-3, a prototype for microsomal P450s

Modeling protein substrate interactions in the heme domain of cytochrome P450_BM-3

Crystal structure and refinement of cytochrome P450_terp at 2.3Å resolution

Identification and characterization of the two functional domains in cytochrome P450_BM-3, a catalytically self-sufficient monooxygenease induced by barbituates in Bacillus megaterium

Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in E. coli: influence of the NH₂-terminal region on localization in cytosol and membranes