Localization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus

doi:10.1016/0896-6273(93)90312-F

Neuron

Volume 10, Issue 2, February 1993, Pages 213-224

https://doi.org/10.1016/0896-6273(93)90312-F Get rights and content

Abstract

Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-α and interleukin-1α in neuronal somata of the striatum following a surgical injury to the hippocampus. The expression of cytokines later extends to neuronal cells of the hippocampus, thalamus, cerebral cortex, brain stem, and cerebellum and to glial cells of the corpus callosum. By contrast, these cytokines are not expressed by neuronal cells following injury to other regions, such as the striatum, cerebellum, and cortex. This study suggests a possible role for certain neurons in the brain's early reaction to a penetrating injury.

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Neuron

ArticleLocalization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus

Abstract

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Neuroscience

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Neuroscience

Immunol. Today

Exp. Neurol.

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Trends Neurosci.

Brain Res.

Expression of tumor necrosis factor in human acute cardiac rejection

Am. J. Pathol.

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

Eur. J. Immunol.

Cellular events associated with peripherally induced rejection of mature neural xenografts placed into neonatal rat brains

J. Comp. Neurol.

Regional and cellular distribution of interleukin 1 beta and nerve growth factor in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis

J. Cell Biol.

Immunologically privileged sites

Adv. Immunol.

Cachectin and tumor necrosis factor as two sides of the same biological coin

Nature

Tumor necrosis, cachexia, shock and inflammation: a common mediator

Annu. Rev. Biochem.

Host response during successful engraftment of fetal xenogenic astrocytes: predominance of microglia and macrophages

J. Neurosci. Res.

Article
Localization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus