Improvement of photostability of ubidecarenone in the formulation of a novel powdered dosage form termed redispersible dry emulsion

https://doi.org/10.1016/0378-5173(92)90027-YGet rights and content

Abstract

Ubidecarenone, which has low photostability and is poorly absorbed in the intestine, was formulated into a novel powdered dosage form designated as a redispersible dry emulsion. In preparing the system, an oily solution containing the drug and a colorant emulsified in an aqueous solution of a surfactant (Pluronic F-68) were spray-dried with a suitable excipient. The resultant dry emulsion particles have good flow properties and readily release the oily droplets to form stable emulsions on rehydration. The redispersibility, i.e., the conversion to the original emulsion from the dry emulsion form, was found to be closely related to the viscosity of the oily carrier. The photostability of the drug dissolved in the oily carriers was much improved in the presence of colorants. The kinetics data for photolytic degradation of the drug in the dry emulsion particle were analyzed to clarify the effect of the amount of excipient and colorant on the photostability of the drug in the particle.

References (16)

There are more references available in the full text version of this article.

Cited by (0)

View full text