Study of natural ascorbigen and related compounds by HPLC
References (27)
- et al.
Mechanisms of anti-carcinogenesis by indole-3-carbinole. Studies on enzyme induction, electrophile-scavenging and inhibition of Aflatoxin B1 activation
Biochemical Pharmacology
(1990) - et al.
Separation of glucosinolates by high-performance liquid chromatography
J. Chromatogr.
(1980) - et al.
High-performance liquid chromatographic method for the determination of 5-vinyl-2-oxazolidinethione in milk
J. Chromatogr.
(1979) - et al.
Differential induction of mixed-function oxidise (MFO) activity in rat liver and intestine by diets containing processed cabbage: Correlation with cabbage levels of glucosinolates and glucosinolate hydrolysis products
Fd Chem. Toxic.
(1987) High-performance liquid chromatography and gas chromatography of organic isothiocyanates and their methanol-isothiocyanate addition compounds
J. Chromatogr.
(1978)- et al.
Identification of candidate cancer chemopreventive agents and their evaluation in animal model and human clinical trials: A review
Cancer Research
(1990) - et al.
Ascorbigen and its derivatives-depot forms of l-ascorbic acid
Bioorg. Khim. (Russ.)
(1987) Investigation of immunomodulating activities of l′-methyl and l′-ethylascorbigens
Antibiotiki i Khimioterapia (Russ.)
(1989)- et al.
Glucobrassicin, the precursor of the thiocyanate ion, 3-indolylacetonitrile, and ascorbigen in Brassica oleracea (and related) species
Ann. Acad. Sci. Fennicae, Ser. A, II, Chemica
(1961)
Neoglucobrassicin, ein zweiter SCN-Precursor vom Indol Typ in Brassica-Arten
Acta Chem. Scand.
Uber die Structur des Ascorbigens
Helv. Chim. Acta
Transformation of ascorbigen in acidic media
Bioorg. Khim. (Russ.)
Cited by (44)
Dissection of the network of indolic defence compounds in Arabidopsis thaliana by multiple mutant analysis
2019, PhytochemistryCitation Excerpt :For the UV dataset a positive correlation between ICHO and IMG (r = 0.51, P = 9.6E-08) and ICHO and a dihydroascorbigen hexose conjugate (r = 0.61, P = 4.2E-11) was observed. Dihydroasc-Hex and, according to this data, presumably also ICHO derive from indole-3-carbinol (Aleksandrova et al., 1992; Gmelin and Virtanen, 1961; Kiss and Neukom, 1966; Wagner and Rimbach, 2009), a degradation product of IMG formed by hydrolysis of indol-3-ylmethylisothiocyanate. In UV-treated leaves, a higher IMG level is directly mirrored by a higher level of these products.
High resolution mass spectrometry studies of sulforaphane and indole-3-carbinol in broccoli
2017, Food ChemistryCitation Excerpt :The determination of SFN by gas chromatography (GC) is also possible (Farag & Abdel Motaal, 2010; Moon, Kim, Ahn, & Shibamoto, 2010), but thermal degradation has been observed (Chiang, Pusateri, & Leitz, 1998). The quantification of I3C is usually performed by LC employing either UV (Ciska & Pathak, 2004) or fluorescence detection (Aleksandrova, Korolev, & Preobrazhenskaya, 1992; Lee et al., 2010). In addition, methods using GC have been reported (Latxague, Gardrat, Coustille, Viaud, & Rollin, 1991; Tolonen et al., 2002).
Ascorbigen: chemistry, occurrence, and biologic properties
2009, Clinics in DermatologyCitation Excerpt :During the degradation of ABG in an acidic medium, AA is released and methylideneindolenine is formed. The 3-indolylmethyl moiety binds to another molecule of ABG to form ABG-dimer, ABG-trimer,28 and 5,11-dihydroindolo[3,2-b]carbazole.29 Preobrazhenskaya et al30 demonstrated a transformation of ABG in mild alkaline media into indole-derived carbohydrates 1-deoxy-1-(3-indolyl)-α-l-sorbopyranose and 1-deoxy-1-(3-indolyl)-α-l-tagatopyranose resulting from the opening of the lactone ring and decarboxylation.
The formation of 2-hydroxy-4-hydroxymethyl-3-(indol-3-yl)cyclopent-2-enone derivatives from ascorbigens
2001, Carbohydrate ResearchCitation Excerpt :This reaction represents a rare example of C-alkylation of l-ascorbic acid under mild conditions (room temperature, buffer at pH 4.2).1–3 Ascorbigen is the most abundant indole-derived dietary ingredient, which humans or animals obtain with cruciferous vegetables.4,5 The anticarcinogenic properties reported for cruciferous vegetables,6 makes studies on chemical and biological properties of ascorbigen important.
Indolocarbazoles
2001, Advances in Heterocyclic Chemistry