The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury
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Adverse effect of superoxide-induced mitochondrial damage in granulosa cells on follicular development in mouse ovaries
2021, Free Radical Biology and MedicineCitation Excerpt :In our previous study using boar sperm, the redox activities of PQQ that kept both integrity of mitochondria DNA and stability of proteins involved in transcription and translation systems in mitochondria were much higher than those of coenzyme Q10 [35]. Moreover, the positive effects of PQQ were also observed in in vivo, such as tissue injury by hypoxic [36], liver damage via oxidative stress [37] or the depletion of glutathione in the embryo [38], indicating that PQQ would improve survivability and quality of granulosa cells. However, the effects of PQQ on follicular development remained unclear.
Ultrasensitive determination of pyrroloquinoline quinone in human plasma by HPLC with chemiluminescence detection using the redox cycle of quinone
2017, Journal of Pharmaceutical and Biomedical AnalysisBeneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer's disease
2017, HeliyonCitation Excerpt :PQQ is considered to be an important nutrient having anti-inflammatory, antioxidative and neuroprotective effects [21, 22]. In animals models, PQQ attenuates neuronal cell death associated with stroke, spinal cord injury and traumatic brain injury [33, 34], by decreasing iNOs expression, protecting NMDA receptor function, decreasing lesion or infarct size and increasing axon density [35, 36]. In neural stem and progenitor cells, PQQ increases the antioxidant enzymes SOD, catalase and glutathione peroxidase [37].
Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in Developing Brain
2017, Models of Seizures and Epilepsy: Second EditionOverexpression of pyrroloquinoline quinone biosynthetic genes affects l-sorbose production in Gluconobacter oxydans WSH-003
2016, Biochemical Engineering JournalCitation Excerpt :Besides its vital functions in the production of many important bulk chemicals [3], PQQ has attracted considerable attention due to its positive physiological effects on growth and development of mammals [6,7]. PQQ has also been recognized as a neuro-protective factor in a rodent model of hypoxic brain injury [8,9], and therefore qualifies as a newcomer to the B group of vitamins [10]. About twenty years ago, Gupta et al. found that the deficiency of pqqE on the genome of G. oxydans IFO 3293 coincided with a deficiency in quinoprotein glucose dehydrogenase activity [11].
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