Intraventricular infusions of antibodies to amyloid-β-protein precursor impair the acquisition of a passive avoidance response in the rat
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Cited by (90)
Role of Environment, Epigenetics, and Synapses in Cognitive Enhancement
2015, Cognitive Enhancement: Pharmacologic, Environmental and Genetic FactorsAmyloid β precursor protein as a molecular target for amyloid β-induced neuronal degeneration in Alzheimer's disease
2013, Neurobiology of AgingCitation Excerpt :For example, application of sAPP to cultured primary neurons promoted long-term survival, enhanced neurite outgrowth, increased synaptic formation, and protected cultured neurons against various toxic stimuli (Mattson, 1997). Extending these observations, intracranial infusion of sAPP-specific antibodies impaired memory, whereas application of sAPP has a memory-enhancing effect (Doyle et al., 1990; Meziane et al., 1998). Together, these findings indicated that sAPP modulates cellular activities involved in cognitive processes, including the functionality and maintenance of synapses and neurites.
Behavioral and neurochemical characterization of mice deficient in the N-type Ca <sup>2+</sup> channel α <inf>1B</inf> subunit
2010, Behavioural Brain ResearchCitation Excerpt :These tests are based on the natural tendency of rodents to alternate in their choices of arms visited when they are placed in a multi-arm maze. Importantly, spontaneous alternation behavior is dependent on intact hippocampal function, supported by the cognitive deficits observed in hippocampal-lesioned rodents [12], making it a relevant task for studying the role of the α1B subunit of N-type calcium channels. In the current study, CaV2.2−/− mice exhibited no significant deficits in spontaneous alternation behavior in the Y-maze.
Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
2008, Neurobiology of DiseaseCitation Excerpt :Given the discrepancies arising from exogenous sAPPα administration, and the potential relevance of decreased protein levels to AD pathogenesis and cognitive decline, it is important to understand the neural effects of reducing the activity of endogenous sAPPα. Studies using sAPP-targeted antibodies in rats and chicks have shown deficits in passive- and active-avoidance memory tasks (Doyle et al., 1990; Huber et al., 1993; Mileusnic et al., 2000), but the antibodies used did not distinguish the functions of sAPPα from related proteins such as sAPPβ (a less potent neurotrophic fragment generated by β- and γ-secretase processing). Here, we have used two strategies to target and inhibit endogenous sAPPα function in the hippocampus, and we have determined the effects of restoring sAPPα with exogenous recombinant protein.
Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning
2008, Behavioural Brain Research