Evidence for a widespread dopaminergic innervation of the human cerebral neocortex
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Cited by (64)
Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease
2021, Neurobiology of AgingCitation Excerpt :Another limitation of this work is the use of the average signal within a reference region to assess relative voxelwise DAT uptakes, a common step in nuclear imaging analysis pipelines. In this work we used the cerebellum as reference region, a commonly used and accepted reference region with postmortem evidence of low DAT density (De Keyser et al., 1989; Palacios et al., 1988). However, we cannot rule out the possibility that PD-specific DAT uptake alterations exist in the cerebellum, which could cause artifacts in the imaging results.
Alterations of neocortical development and maturation in autism: Insight from valproic acid exposure and animal models of autism
2013, Neurotoxicology and TeratologyCitation Excerpt :As for the frontal cortex, many would agree that this neocortical region receives the highest density of dopaminergic fibres. However, with respect to more posterior networks, and the temporal association area in particular, there is a general assumption that this region lacks dopaminergic innervation (De Keyser et al., 1989). However, several human and animal studies have suggested that this is indeed not the case (Bao et al., 2001; De Keyser et al., 1989; Descarries et al., 1987; Liu et al., 2004; Smiley et al., 1992), lending further support to the notion that hyperdopaminergia may lead to dysregulated brain growth in both frontal and temporal association regions.
Sleep Disorders in Parkinson's Disease and Parkinsonian Syndromes
2012, Therapy in Sleep MedicineThe Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective
2007, International Review of NeurobiologyCitation Excerpt :In particular, these DA projections into the VS are considered to be crucial for motivation and reward seeking (Everitt and Robbins, 2005; Iversen, 1984). Finally, the mesocortical DA system is composed of DA neurons also located in the VTA that project to the prefrontal cortex (PFC), anterior cingulate, and entorhinal cortex in rodents (Fallon et al., 1978; Thierry et al., 1973) as well as additional neocortical and even cerebellar areas in primates and humans (De Keyser et al., 1989; Lewis et al., 1987; Melchitzky and Lewis, 2000; Moore et al., 2003). The PFC is considered to be the highest center of cognition (Funahashi, 2001; Fuster, 1997; Goldman‐Rakic, 1995; Knight et al., 1995; Robbins, 2000; Shimamura, 2000), and DA release in the PFC is essential for its function.
Parkinsonism
2005, Principles and Practice of Sleep Medicine