Labeled corticospinal neurons one year after spinal cord transection☆
References (8)
- et al.
Cell death in the adult dorsal root ganglion after hind limb amputation, spinal cord transection, or both operations
Exp. Neurol.
(1985) Letter to Editor
Neurology
(1984)- et al.
Histologic evidence for death of cortical neurons after spinal cord transection
Neurology
(1984) - et al.
Cell death in Clarke's column after spinal cord transection
J. Neuropathol. Exp. Neurol.
(1985)
Cited by (32)
Inhibition of neogenin promotes neuronal survival and improved behavior recovery after spinal cord injury
2019, NeuroscienceCitation Excerpt :Although some authors reported a substantial decrease in the number of CST neurons in the rat brain (Feringa et al., 1984; Giehl and Tetzlaff, 1996; Hains et al., 2003; Lee et al., 2004), others recently failed to confirm death of axotomized CST neurons after SCI (Nielson et al., 2010, 2011). However, the discrepancy may be because a briefer observation time after SCI was used in some studies (2 weeks) than in others (up to one year) (Feringa and Vahlsing, 1985). Our previous experiments showed that the majority of “bad regenerating” RS neurons express Neogenin and that expression of RGMa is downregulated near the transection site in earlier stages of regeneration (Shifman et al., 2009).
Cortical morphometric changes after spinal cord injury
2018, Brain Research BulletinCitation Excerpt :A large-scale degeneration would then result in atrophy especially of sensorimotor cortical regions. Indeed, animal models of SCI have shown a significant decrease in the size or number of neurons in sensorimotor areas of the brain after spinal cord transection (Pernet and Hepp-Reymond, 1975; Feringa and Vahlsing, 1985; Hains et al., 2003; Lee et al., 2004; Kim et al., 2006). However, the study of acute and progressive structural changes in human SCI is challenging for several reasons.
Brain sensorimotor system atrophy during the early stage of spinal cord injury in humans
2014, NeuroscienceCitation Excerpt :This can generate a special condition in the brain since disconnected sensorimotor areas are preserved while their efferent motor commands do not reach the effectors and no longer receive appropriate afferent feedback (Curt et al., 2002a). Previous animal models of SCI have shown a significant decrease in the size or number of neurons in sensorimotor areas of the brain after spinal cord transection (Pernet and Hepp-Reymond, 1975; Feringa and Vahlsing, 1985; Hains et al., 2003; Lee et al., 2004; Kim et al., 2006). However, it is currently unclear whether and how brain sensorimotor areas react to such a condition in humans.
Cortical motor areas and their properties: Implications for neuroprosthetics
2000, Progress in Brain Research
- ☆
A preliminary report of this data was presented at the American Academy of Neurology 1985 meeting in Dallas, TX, U.S.A.