Elsevier

Biochimie

Volume 77, Issue 10, 1995, Pages 765-773
Biochimie

Review
Geminivirus replication: Genetic and biochemical characterization of rep protein function, a review

https://doi.org/10.1016/0300-9084(96)88194-6Get rights and content

Abstract

Replication of the single-stranded DNA genome of plant geminiviruses follows a rollin circle mechanism. It strictly depends on a ‘replication initiator protein’ (Rep) which is the sole viral protein essential for replication. Rep protein catalyzes multiple reactions duringthe reproductive cycle of the virus. Here we summarize the recent advances of in vivo and in vitro analyses of the various Rep protein activities in a model for replication initiation and termination. In addition, the position of the geminivirus Rep protein within a general context of bacterial and mammalian replication initiator proteins is discussed.

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