Research reportEffect of serotonin on cytokine mRNA expression in rat hippocampal astrocytes
References (42)
- et al.
Induction and regulation of interleukin-6 gene expression in rat astrocytes
J. Neuroimmunol.
(1990) - et al.
Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control
J. Biol. Chem.
(1992) - et al.
Single step method of RNA isolation by acid guanidium thiocyanate phenol-chloroform extraction
Anal. Biochem.
(1987) Interleukin-1 and its biologically related cytokines
Adv. Immunol.
(1989)- et al.
Regulation of IL6 secretion in primary cultured rat astrocytes: synergism of IL1 and pituitary adenylate cyclase activating polypeptide PACAP
Brain Res.
(1994) - et al.
5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions in the brain
Neuropharmacology
(1987) Regional heterogeneity among astrocytes in the central nervous system
Neurochem. Int.
(1990)- et al.
Transforming growth factor-β1 and -β2 promote neurite sprouting and elongation of cultured rat hippocampal neurons
Brain Res.
(1994) - et al.
In vivo and in vitro development of serotoninergic neurons
Brain Res. Bull.
(1982) - et al.
Neuron-glia interactions: effect of serotonin on the astroglial expression of GFAP and of its encoding message
Dev. Brain Res.
(1990)
Functional receptors for neurotransmitter on astroglial cells
Neuroscience
Expression of cytokine receptors in cultured neuronal and glial cells
Neurosci. Lett.
Biological active A-chain of the plant toxin ricin expressed from a synthetic gene in Escherichia coli
Gene
Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6
Brain Res.
Serotonin inhibition of tumor necrosis factor α synthesis by human monocytes
Life Sci.
Tumor Necrosis Factor-alpha production by astrocytes. Induction by lipopolysaccharides, IFN-gamma and IL1-beta
J. Immuol.
Detection of 5-hydroxytryptamine 2 receptors by radioligand binding, Northern blot analysis, and Ca2+ responses in rat primary astrocytes cultures
J. Neurosci. Res.
A comprehensive set of sequence analysis programs for the VAX
Nucleic Acids Res.
IL1 and TNF synergistically stimulate fibroblasts induction ans stabilize IL6 messenger RNA
J. Immunol.
Cytokine regulation of substance P expression in sympathetic neurons
Brain IL1 and S100β immunoreactivity are elevated in Down syndrome and Alzheimer disease
Cited by (38)
Integrating the monoamine, neurotrophin and cytokine hypotheses of depression - A central role for the serotonin transporter?
2015, Pharmacology and TherapeuticsCitation Excerpt :A large body of evidence exists for 5-HT receptor involvement in immune modulation in the periphery (Meredith et al., 2005; Ahern, 2011; Baganz & Blakely, 2013). Moreover, 5-HT by acting at 5-HT7 receptors induces cytokine expression in astrocytes (Pousset et al., 1996; Lieb et al., 2005) and microglia (Mahe et al., 2005). Serotonin appears to have distinct effects on microglia activation, i.e. serotonin receptor activation enhances injury-induced motility of microglia processes but decreases their phagocytic activity (Krabbe et al., 2012).
Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT<inf>4</inf>, 5-HT<inf>6</inf> and 5-HT<inf>7</inf> receptors
2012, NeuroscienceCitation Excerpt :Thus, spinal 5-HT could reach these receptors and influence astrocytes which may then release nociceptive mediators. In support of this, 5-HT is able to stimulate the expression of interleukin-6, tumor necrosis factor alpha (TNFα) or transforming growth factor beta (TGFβ) mRNA in astrocytes and microglia (Pousset et al., 1996; Mahe et al., 2005) and this effect is abolished by a selective 5-HT7 receptor antagonist (Lieb et al., 2005; Mahe et al., 2005). Taken together, data suggest that formalin activates RVM (Wei et al., 2010; Ambriz-Tututi et al., 2011) which in turn stimulates serotonergic neurons that then increase 5-HT concentration (Marshall et al., 2012, this study) at the dorsal horn of the spinal cord activating 5-HT4/6/7 receptors (this study).
Effects of central and peripheral depletion of serotonergic system on carrageenan-induced paw oedema
2005, International Immunopharmacology