Elsevier

Archives of Gerontology and Geriatrics

Volume 9, Issue 3, November–December 1989, Pages 291-296
Archives of Gerontology and Geriatrics

Erythrocyte membrane changes associated with nutrition and aging — the role of plasmalogens

https://doi.org/10.1016/0167-4943(89)90049-6Get rights and content

Abstract

Fatty aldehyde dimethylacetals (DMA) derived from human plasma and red cell plasmalogens of 20 female and 20 male donors, aged 70 years and over, and of 17 younger ones (12 male, 5 female), were measured as part of total phospholipid fatty acid methyl esters and DMA. There were no statistically significant changes in the hexadecanal DMA fractions of erythrocyte membranes with respect to donor age. In contrast, small degrees of correlation, though statistically significant, indicate a stochastic decline with donor age of erythrocyte octadecanal DMA and of plasma-derived hexadecanal DMA and octadecanal DMA levels. It is concluded that in the context of age-related changes not only the plasmalogen content of biomembranes has to be considered. Because of the sensitivity of plasmalogens to autoxidation, effects of oxidative damage and defense on membrane architecture, the degree of plasmalogen domain formation with its implication on membrane functions and the mechanisms regulating membrane turnover have to be also assessed.

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    Data for these 2 plasmalogen pools suggest that alterations in plasmalogens in schizophrenia are more likely the result of alterations in lipid transport and/or in lipid metabolism/remodeling, rather than alterations in plasmalogen synthesis. Deficits in the levels of circulating or erythrocyte plasmalogens have also been demonstrated in patients with primary-open angle glaucoma (Acar et al., 2009), peroxisomal disorders (Aubourg and Wanders, 2013), metabolic syndrome (Brosche, 2001; Kaddurah-Daouk et al., 2007), renal failure (Stenvinkel et al., 1998, 2004; Brosche et al., 2002; Yamazaki et al., 2014), cardiovascular disease (Hoerrmann et al., 1991; Brosche et al., 2007; Maeba et al., 2007; Graessler et al., 2009; Nishimukai et al., 2014), sepsis (Brosche et al., 2013), Parkinsons' disease (Dragonas et al., 2009), Alzheimer's disease (Goodenowe et al., 2007; Wood et al., 2010; Oma et al., 2012; Trushina et al., 2013), and decreases with aging (Brosche et al., 1989; Maeba et al., 2007; Goodenowe et al., 2007). However, except for children with peroxisomal disorders, these reported decreases are all in more elderly patients, while plasmalogen decrements in schizophrenia also occur in young, first episode, non-medicated patients as well as older medicated patients (Kaddurah-Daouk et al., 2012).

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Presented in the program of a Symposium entitled ‘Aging at the Molecular, Cellular and Organism Level’ held on the occasion of the 10th anniversary of the Gerontological Institute of Friedrich-Alexander University of Erlangen-Nürnberg, 3rd June, 1989, Nürnberg, F.R.G.

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