Review
Sexual differentiation of the human hypothalamus in relation to gender and sexual orientation

https://doi.org/10.1016/0166-2236(95)80007-OGet rights and content

Abstract

Recently, sex differences in the structures of the human hypothalamus and adjacent brain structures have been observed that seem to be related to gender, to gender problems such as transsexuality, and to sexual orientation, that is, heterosexuality and homosexuality. Although these observations have yet to be confirmed, and their exact functional implications are far from clear, they open up a whole new field of physiological structural-functional relationships in human brain research that has so far focused mainly on such relationships in pathology.

References (61)

  • D.F. Swaab et al.

    Prog. Brain Res.

    (1984)
  • D. Kimura et al.

    Prog. Brain Res.

    (1984)
  • N. Rance

    Prog. Brain Res.

    (1992)
  • J. Money et al.

    Psychoneuroendocrinology

    (1984)
  • R.H. Anderson

    Brain Res.

    (1986)
  • J.B. Hutchison

    Curr. Opin. Neurobiol.

    (1991)
  • D.F. Swaab et al.

    Prog. Brain Res.

    (1992)
  • F.J.C.M. Van Eerdenburg et al.

    Neurosci. Lett.

    (1991)
  • R.A. Gorski

    Brain Res.

    (1978)
  • J.L. Turkenburg

    Brain Res. Bull.

    (1988)
  • F.H. De Jonge

    Brain Res. Bull.

    (1989)
  • G. Bloch et al.

    Brain Res.

    (1993)
  • R. Ravid et al.

    Prog. Brain Res.

    (1992)
  • D.F. Swaab

    Dev. Brain Res.

    (1994)
  • D.F. Swaab et al.

    Brain Res.

    (1990)
  • J.N. Zhou

    Brain Res.

    (1995)
  • M.A. Hofman et al.

    Brain Res.

    (1994)
  • D.F. Swaab

    Dev. Brain Res.

    (1995)
  • E.J. Houtsmuller

    Physiol. Behav.

    (1994)
  • A. Fausto-Sterling
    (1992)
  • C. Pilgrim et al.

    Horm. Metab. Res.

    (1992)
  • A. Whitaker

    Psychiatr. Med.

    (1989)
  • E.Z. Susser et al.

    Arch. Gen. Psychiatry

    (1992)
  • D.A. Regier

    Arch. Gen. Psychiatry

    (1988)
  • E.D. Acheson

    Br. Med. Bull.

    (1977)
  • D.J. Castle et al.

    Psychiatr. Med.

    (1991)
  • A.J. Block

    New Engl. J. Med.

    (1979)
  • E.D. Caine

    Neurology

    (1988)
  • A. Bakker

    Acta Psychiatr. Scand.

    (1993)
  • B.L. Miller

    J. Neurol. Neurosurg. Psychiatry

    (1986)
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