Trends in Pharmacological Sciences
Muscarinic acetylcholine receptor subtypes in smooth muscle
References (50)
Pharmacol. Ther.
(1993)Pharmacol. Ther.
(1988)- et al.
Eur.J. Pharmacol.
(1988) - et al.
Eur. J. Pharmacol.
(1987) - et al.
Eur. J. Pharmacol.
(1988) - et al.
Eur. J. Pharmacol.
(1990) - et al.
Eur. J. Pharmacol.
(1985) Eur. J. Pharmacol.
(1988)- et al.
FEBS Lett.
(1988) Life Sci.
(1993)
Life Sci.
Eur. J. Pharmacol.
Eur. J. Pharmacol.
Gastroenterology
Br. J. Pharmacol.
J. Pharm. Pharmacol.
Trends Pharmacol. Sci.
Br.J. Pharmacol.
J. Recept. Res.
Naunyn-Schmied. Arch. Pharmacol.
Br. J. Pharmacol.
Naunyn-Schmied. Arch. Pharmacol.
J. Auton. Pharmacol.
J. Pharm. Pharmacol.
Br. J. Pharmacol.
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Label free impedance based acetylcholinesterase enzymatic biosensors for the detection of acetylcholine
2023, Biosensors and BioelectronicsVasoreactivity to Acetylcholine During Porcine Kidney Perfusion for the Assessment of Ischemic Injury
2019, Journal of Surgical ResearchCitation Excerpt :Increasing the WIT from 15 min to 60 and 90 min attenuated the vasodilator response to ACh. Administration of ACh in doses ≥10−7 mmol/L produced an opposite vasoconstrictor response, in keeping with the literature which suggests higher concentrations of ACh diffuse through the endothelium to exert a direct effect on muscarinic receptors in the vascular smooth muscle.21 This theory is supported by a study of renal intra-arterial injection of ACh in cats.22
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2019, International Journal of Biological MacromoleculesOrgan-Specific Autoimmunity Involvement in Cardiovascular Disease
2017, Handbook of Systemic Autoimmune DiseasesRelaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase
2017, European Journal of PharmacologyCitation Excerpt :The pD2′ value of apigenin against histamine- was significantly greater than that [3.06 ± 0.13 (n = 6)] against carbachol-induced contractions, suggesting that the antispasmodic effects of apigenin against histamine are greater than those against carbachol. Although the reason is not clear, it has been established that carbachol may activate muscarinic M2 receptors, a major (80%) receptor population, via a pertussis-toxin-sensitive G protein, Gi, which inhibits adenylate cyclase activity (Eglen et al., 1994) and causes an indirect contraction thus attenuating the relaxant effects of apigenin. The above results of the in vitro study clearly suggest that apigenin is a non-specific antispasmodic, although it cannot reach the blood concentrations of 100 and 200 μM due to its cytotoxicity in vivo.
Roles of ion channels in regulation of acetylcholine-mediated vasoconstrictions in umbilical cords of rabbit/rats
2016, Reproductive ToxicologyCitation Excerpt :Lacking autonomic innervation, regulation of umbilical vascular tone mainly depends on release of vasoactive substances [1]. Acetylcholine (ACh) is the most common cholinergic chemical in the organs of the body, including the placenta and umbilical vessels [2,3] as well as in other smooth muscle cells [4–6]. Based on others’ and our studies on human umbilical arteries and veins, as well as our recent findings in rats and sheep [7], this study tested rabbit and rat umbilical cords in order to determine ACh’s special actions on umbilical vessels.