Trends in Pharmacological Sciences
The value of infusion and injection regimens in assessing efficacy and toxicity of drugs
References (16)
- et al.
Life Sci.
(1981) - Nau, H., Merker, H. J., Brendel, K., Gansau, C., Hauser, I. and Wittfoht, W. Metabolism of Anti-epileptic Drugs, Raven...
- et al.
Cancer Treat. Rep.
(1978) - et al.
Arch. Ophthalmol.
(1976) - et al.
Clin. Pharmacol. Ther.
(1981) Recent Prog Horm Res.
(1980)Drugs
(1982)- et al.
Br. J. Cancer
(1980)
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Novel intrathecal and subcutaneous catheter delivery systems in the mouse
2016, Journal of Neuroscience MethodsCitation Excerpt :For this reason, peripheral drug delivery systems are an intricate component of studying neurological diseases in a rodent model. Though multiple injection protocols are commonly used to deliver drugs to peripheral regions, they cannot achieve consistent drug delivery over an extended period of time (Fara and Urquhart, 1984; Perkins et al., 2004). Further, repeated injections expose the animal to excessive handling and injury, often confounding the results of physiological and behavioral experiments (Wright and Lincoln, 1985; Dilsaver and Majchrzak, 1990; Lafarga et al., 1998; Vinkers et al., 2009; Drude et al., 2011).
An animal model to study health effects during continuous low-dose exposure to the nerve agent VX
2008, ToxicologyCitation Excerpt :Another, or contributing explanation, could be that body weight gain is a parameter that is more susceptible to continuous exposure, compared to repeated injections. It has previously been suggested that many biological signalling systems respond differently to repeated versus continuous administration (Lotinun et al., 2002; Fara and Urquhart, 1984). One previous study in mice, comparing repeated daily injections of isoproterenol to continuous infusion through an osmotic pump, showed that these regimens had different effect on blood pressure (Hohimer et al., 2005).
Serotonin receptor blockade increases food intake and body weight after total gastrectomy in rats
2002, Journal of Surgical ResearchDifferential routes of cocaine administration indicate a peripheral cardiotoxic action
1991, Pharmacology, Biochemistry and BehaviorClinical pharmacology approaches to the assessment of novel drug delivery concepts
1990, Journal of Controlled Release
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John Fara, Ph.D., is Principal Scientist and Director of Biomedical Research at ALZA. He received his doctorate in Physiology from the University of California at Los Angeles, did post-doctoral work with Prof. Bjorn Folkow at the University of Goteborg, and has held academic appointments at UCLA, State University of New York at Stony Brook, and John Hopkins University Prior to joining ALZA in 1979, he was Associate Professor of Radiology and of Physiology and Director of Radiology Research at Johns Hopkins University Medical School.
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John Urquhart, MD, is Senior Vice-President at ALZA Dr Urquhart is a graduate of Rice University and Harvard Medical School, and Past-President of the Biomedical Engineering Society Before joining ALZA in 1971, he was Professor of Biomedical Engineering at the University of Southern California and Professor of Physiology at the University of Pittsburgh School of Medicine.