Journal of the Autonomic Nervous System
Short communicationThe norepinephrine tissue concentration and neuropeptide Y immunoreactivity in genitourinary organs of the spontaneously hypertensive rat
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Cited by (43)
Underlying mechanisms of urine storage dysfunction in rats with salt-loading hypertension
2015, Life SciencesCitation Excerpt :It has been demonstrated that patients with BPH with concomitant HT have more severe LUTS and that accordingly, more severe LUTS are associated with an increased odds ratio for elevated BP [13]. Considering the increased sympathetic innervations and neurotransmitters in the SHR bladder and prostate, enhanced sympathetic activity is likely to be a pathophysiological factor accounting for the relationship between HT and LUTS [13,14]. Elevated NGF secretion by bladder smooth muscle is also associated with hyperinnervation and detrusor overactivity [3,15].
Increased TRH and TRH-like peptide release in rat brain and peripheral tissues during proestrus/estrus
2014, PeptidesCitation Excerpt :Lower levels of receptor were detectable in submandibular gland, heart, lung, stomach, pancreas, spleen, kidney, liver, intestine, placenta, and prostate [17]. Contraction [71] and growth [40] of the prostate and epididymis are activated by noradrenergic sympathetic innervation of the membrane-bound and intracellular α1-adrenoceptors found throughout the ejaculatory system of rat and man [10]. Very low levels of the α1-adrenoceptor inhibitor, prazosin, stimulated release of the TRH and TRH-like peptides from the prostate and epididymis suggesting a role for these peptides in the ejaculatory process [64].
Interactions of neuropeptide y, catecholamines, and angiotensin at the vascular neuroeffector junction
2013, Advances in PharmacologyCitation Excerpt :Additionally, there is considerable evidence implicating a role for both peripheral and central NPY in the development and maintenance of hypertension in humans and experimental models such as the SHR (reviews: Michel & Rescher, 1995; Pedrazzini, Pralong, & Grouzmann, 2003; Westfall, 2006). First, there are numerous reports of a more dense innervation of NPY-containing nerves and higher NPY levels in both prehypertensive and adult SHR compared to normotensive controls (Dhital et al., 1988; Fan, Hendley, & Forehand, 1995; Fujimoto, Ito, & Sekine, 1993; Gradin et al., 2003; Kawamura, Ando, & Takebayashi, 1989; Kawamura & Takebayashi, 1991; Lee, Nagahama, McKenzie, & Daniel, 1988; Morris, 2004; Tong et al., 1996). It is also significant that the increase in innervation increases with age in the SHR and precedes hypertension and the associated medial hypertrophy (Fan et al., 1995).
Rapid modulation of TRH and TRH-like peptide release in rat brain and peripheral tissues by prazosin
2011, PeptidesCitation Excerpt :The most striking observation in the present study was the nearly quantitative release/clearance of all TRH and TRH-like peptides from the prostate and epididymis at even a very low dose of prazosin 4 h after injection. Contraction [60] and growth [34] of the prostate and epididymis are activated by noradrenergic sympathetic innervation of the membrane-bound and intracellular α1-adrenoceptors found throughout the ejaculatory system of rats and man [13]. Prazosin and other α1-adrenoceptor inhibitors are used for the treatment of the urologic complications of benign prostatic hypertrophy [13].
Acute vardenafil administration improves bladder oxygenation in spontaneously hypertensive rats
2010, Journal of Sexual MedicineCitation Excerpt :We here hypothesized that treatment with PDE5i could increase bladder blood flow and tissue oxygenation, thus counteracting ischemia/hypoxia-related tissue dysfunction. In the present study, SHR, a well-established model of genetically induced hypertension and OAB [17], were treated acutely with a single administration of the PDE5i vardenafil, 90 minutes before sacrifice. Hypoxia was evaluated using the hypoxyprobe kit, a generally accepted marker for quantification of tissue hypoxia [9,12,13,30–33].
Physiological and pathological regulation of the autonomic control of urinary bladder contractility
2008, Pharmacology and Therapeutics