Cell
Volume 76, Issue 2, 28 January 1994, Pages 357-369
ArticleHhal methyltransferase flips its target base out of the DNA helix
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Cited by (941)
tRNA m<sup>1</sup>G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10
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2022, Biophysical JournalCitation Excerpt :The biological relevance of the protein residues involved in the observed interactions was further scrutinized by analyzing their conservation among eukaryotic amino acid sequences. Finally, we observed a base flipping event as well as the flipping of FL2 into the transcription bubble, in line with previous experiments (7,15,55,56,57). Mutagenesis experiments targeting the fork loops and the rudder have been carried out in archaeal RNAP II and have revealed that the rudder helps in stabilizing the melted DNA in the OC (58).
Mechanistic study on DNA mutation of the cytosine methylation reaction at C5 position
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