Cell
ArticleSynemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle
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Inactivation of vimentin in satellite glial cells affects dorsal root ganglion intermediate filament expression and neuronal axon growth in vitro
2021, Molecular and Cellular NeuroscienceCitation Excerpt :The peripherin expression was unaffected by synemin deletion, suggesting that peripherin expression in small DRG neurons is independent of the presence of synemin. This result confirms that synemin acts more as an IF-associated protein in the small DRG neurons, which cannot organize itself into a cytoplasmic network but must bind to preexisting filaments to form a network (Granger and Lazarides, 1980; Green et al., 2005). In contrast, a significant decrease in peripherin expression was noted among small regenerating vim−/− DRG neurons after sciatic nerve injury.
Absence of synemin in mice causes structural and functional abnormalities in heart
2018, Journal of Molecular and Cellular CardiologyCitation Excerpt :Although our study is the first to show altered cardiac function related to the absence of synemin, cardiomyopathies (CM) have previously been linked to other IF proteins. Dilated CM, arrhythmogenic right ventricular CM and mixed CM with arrhythmia are associated with abnormalities in proteins of the IF superfamily, such as desmin, lamin A and lamin C [37–44]. Concentric hypertrophy, cardiac dilation with compromised systolic function due to fibrosis, calcification, lateral misalignment of myofibrils, changes in the dimensions of individual cardiomyocytes, as well as decreases in active force generation, have been reported in desmin-null mice [38,44–46].
Synemin Molecular Features and the Use of Proximity Ligation Assay to Study Its Interactions
2016, Methods in EnzymologyCitation Excerpt :However, whether synemin actually copolymerizes with these keratins has yet to be examined. In the normal adult, synemin is primarily found in contractile cells, namely striated and smooth muscle (Bilak et al., 1998; Granger & Lazarides, 1980) and myoepithelial cells (Hirako et al., 2003; Table 1). β-Synemin is the predominant isoform in contractile cells (Mizuno, Thompson, et al., 2001).
Thyroxine-induced cardiac hypertrophy: Role of ascorbic acid in treatment
2014, Biomedicine and Aging PathologyIdentification and cytoprotective function of a novel nestin isoform, Nes-S, in dorsal root ganglia neurons
2013, Journal of Biological Chemistry