Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone☆

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Abstract

The immediate and late obstructive reactions after house dust inhalation were studied in 10 patients with reversible obstructive lung disease. The immediate obstructive reactions were of the conventional type. The late obstructive reactions occurred 4 to 8 hours after the allergen challenge and in this respect followed the time table of the Arthus reaction but were otherwise clearly distinct from the conventional Arthus reaction: marked bronchial obstruction, no crepitations, no fever, and no leukocytosis. Disodium cromoglycate showed an evident protective effect on the immediate reactions in contrast to prednisolone, which produced no protection in this type of reaction. There was a marked inhibitory effect on the late obstructive reaction with prednisolone and with disodium cromoglycate.

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    ☆

    Supported by grants from the National Research Council TNO, The Netherlands (GO 623 C21), and the European Community of Coal and Steel, Luxemburg (6240-21-0.81).

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