Analysis of 138 consecutive ovarian cancer patients: Incidence and characteristics of familial cases

doi:10.1016/0090-8258(90)90256-K

Gynecologic Oncology

Volume 39, Issue 3, December 1990, Pages 300-304

https://doi.org/10.1016/0090-8258(90)90256-K Get rights and content

Abstract

Eight families with two or more first-degree relatives affected with ovarian carcinoma were identified among a series of 138 consecutive ovarian cancer patients. History of breast cancer was reported in six of the eight families. Five of 19 patients with familial cancer developed ovarian cancer as a second primary tumor following breast carcinoma, whereas only $6130$ sporadic cases had a previous history of breast cancer. No significant difference was detected in clinical and pathological features between sporadic and familial cases. However, in three high-risk families ovarian cancer tended to develop at a younger age compared with other familial cases and with sporadic occurrences, and nulliparity was less frequent in the familial group. These observations emphasize the need to take into account multiple factors—in addition to positive family history—for the evaluation of genetic predisposition to ovarian carcinoma.

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Analysis of 138 consecutive ovarian cancer patients: Incidence and characteristics of familial cases

Abstract

Amer. J. Med.

Gynecol. Oncol.

Gynecol. Oncol.

Gynecol. Oncol.

Determinants of ovarian cancer risk. I. Reproductive experiences and family history

J. Natl. Cancer Inst.

An epidemiologic study of epithelial carcinoma of the ovary

Amer. J. Epidemiol.

Hereditary ovarian cancer clinical and biomarker studies

Familial ovarian carcinoma

JAMA

Six families prone to ovarian cancer

Cancer

Familial ovarian cancer: A population-based case-control study

Amer. J. Epidemiol.

Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families

Genetic analysis of human breast cancer: Implications for family study designs

Genet. Epidemiol.

Familial ovarian cancer registry

Obstet. Gynecol.

An epidemiologic study of the relationship of reproductive experience to cancer of the ovary

Amer. J. Epidemiol.

Hereditary cancer, oncogenes, and antioncogenes

Cancer Res.