PaperAspirin fails to inhibit platelet aggregation in sheep☆
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Cited by (18)
A comprehensive study of ovine haemostasis to assess suitability to model human coagulation
2014, Thrombosis ResearchCitation Excerpt :The inability of the ovine platelets to respond to human TRAP-6 may be similar to that of pig, rabbit, dog and hamster, which carry differences in the thrombin receptor and thus reactivity to thrombin-receptor derived peptides [28]. Although higher concentrations of AA and ristocetin did induce ovine platelet aggregation using PRP-based methods [17,29,30], this was not documented using Multiplate® analysis [7]. It is postulated that this disparity in ovine platelet responsiveness is due to a differing mechanism of action by the agonist or qualitative and/or quantitative differences in the platelet membrane receptor [29].
Changes of platelet function and blood coagulation during short-term storage of CPDA-1-stabilised ovine blood
2011, Research in Veterinary ScienceCitation Excerpt :Choi and Pai (2003) reported that especially the second wave of ADP-induced aggregation which is produced by endogenous ADP release is lost during 24 h storage at room temperature. In contrast to human platelets that typically undergo a biphasic aggregation, ovine and canine platelets usually show a monophasic, primary response to ADP (Spanos, 1993). Astonishingly, only little changes of plasmatic coagulation were observed during the observation period of 72 h. Individual coagulation factors were not measured in this study, but studies on human and canine blood bags indicate that factors V and VIII:C show a low storage stability (Hondow et al., 1982; Nolte et al., 1988).
Animal models for the assessment of novel vascular conduits
2010, Journal of Vascular SurgeryCitation Excerpt :Measures of blood coagulation in sheep undergoing vascular surgery are similar to those found in humans, but these animals do exhibit a number of hematologic differences along with a tendency to hypercoagulability, as outlined earlier. Sheep can be anticoagulated with heparin and warfarin, although at generally higher doses than those used for humans; however, the response to clopidogrel is modest, and aspirin fails to inhibit platelet aggregation.100-102 The ovine carotid artery is readily accessible and similar in diameter to human peripheral arteries.
Experimental Studies for Small Diameter Grafts in an in Vivo Sheep Model-Techniques and Pitfalls
2021, Thoracic and Cardiovascular Surgeon
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Presented in part to the Australian Physiological and Pharmacological Society, May 1982, (Abstract 36p).