Extensive antigenic heterogeneity of foot-and-mouth disease virus of serotype C
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Cited by (87)
Inherent biophysical stability of foot-and-mouth disease SAT1, SAT2 and SAT3 viruses
2019, Virus ResearchCitation Excerpt :The degree to which immunity induced by one virus is effective against another is largely dependent on the antigenic differences between them. Foot-and-mouth disease (FMD) virus (FMDV), a member of the genus Aphthovirus within the family Picornaviridae, is an example of an antigenically variable pathogen with the capacity to evade the immune response (Martínez et al., 1992; Mateu et al., 1988). FMD remains one of the most economically important diseases of livestock, such as cattle, sheep, pigs and goats (Gibbs, 1981; Sutmoller et al., 2003; Perry and Rich, 2007).
Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I: C)
2014, Veterinary MicrobiologyCitation Excerpt :In these cases, cellular immunity may have an important function against viral infection. Low immunogenicity and weakness of cross-protection are the major drawbacks for peptide or epitope-based protein vaccines (Mateu et al., 1988; Francis et al., 1990; Sin and Weiner, 2000; Mayr, 2001; Trumpfheller et al., 2012). Thus, combining a multi-epitope protein with a potent cellular immune stimulator may be an effective strategy to broaden cross-protection and improve the immunogenicity of epitope-based vaccines.
Improved neutralising antibody response against foot-and-mouth-disease virus in mice inoculated with a multi-epitope peptide vaccine using polyinosinic and poly-cytidylic acid as an adjuvant
2012, Journal of Virological MethodsCitation Excerpt :The hypervariability of the immunodominant G–H loop domain has been a major drawback of VP1-based immunogens. Amino acid substitutions in the G–H loop domain alter the interaction of FMDV with neutralising antibodies (Taboga et al., 1997; Mateu et al., 1988; Francis et al., 1990). The alteration occurs when the loop epitope of a vaccine does not match that of a virus causing an FMD outbreak.
Quasispecies as a matter of fact: Viruses and beyond
2011, Virus ResearchCitation Excerpt :Virologists presently use the term quasispecies to mean distributions of non-identical but related genomes subjected to a continuous process of genetic variation, competition, and selection, and which act as a unit of selection (Domingo, 2006; Perales et al., 2010). Following the Qβ work, quasispecies dynamics was documented with foot-and-mouth disease virus in cell culture and in vivo (Domingo et al., 1980; Sobrino et al., 1983), including the concept that antigenic heterogeneity was a consequence of genetic heterogeneity (Mateu et al., 1987, 1988, 1989; review in Domingo et al., 2003). In parallel, Holland and his colleagues interpreted the competition-selection dynamics between vesicular stomatitis virus (VSV) and their corresponding defective-interfering (DI) particles in the light of high mutation rates and quasispecies dynamics (Holland, 1984; Holland et al., 1982; Semler and Holland, 1979; Spindler et al., 1982).
Production and characterization of two serotype independent monoclonal antibodies against foot-and-mouth disease virus
2007, Veterinary Immunology and Immunopathology
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Present address: Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333.