Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia
References (38)
- et al.
Arachidonic acid as a messenger in the central nervous system
- et al.
Role of metals in oxygen radical reactions
Free Rad. Biol. Med.
(1985) - et al.
A mouse model of focal cerebral ischemia for screening neuroprotective drug effects
J. Pharm. Meth.
(1992) - et al.
Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation
Biochim. Biophys. Acta
(1988) - et al.
The effects of two 21-aminosteroids on overt infarct size 48 hours after middle cerebral artery occlusion in the rat
Brain Res.
(1991) Glutamate neurotoxicity and diseases of the nervous system
Neuron
(1988)- et al.
The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum
Neurosci. Lett.
(1994) - et al.
Central nervous system trauma and stroke
Free Rad. Biol. Med.
(1989) - et al.
Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid
Biochem. Biophys. Res. Commun.
(1993) - et al.
Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase
Biochem. Pharmacol.
(1992)
Ischemia-induced brain iron delocalization: effects of iron chelators
Free Rad. Biol. Med.
Hepatic lipoate uptake
Arch. Biochem. Biophys.
Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol
Biochim. Biophys. Acta
Allosteric modulation of the NMDA receptor by dihydrolipoic acid and lipoic acid in rat cortical neurons in vitro
Neuron
The expression, localization and functional significance of β-nerve growth factor in the central nervous system
Brain Res. Rev.
Thresholds in cerebral ischemia: the ischemic penumbra
Stroke
Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
J. Neurochem.
Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia
Stroke
Oxygen radicals in focal cerebral ischemia
Brain Pathol.
Cited by (89)
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion
2017, Food and Chemical ToxicologyTargeting G protein coupled receptor-related pathways as emerging molecular therapies
2015, Saudi Pharmaceutical JournalStudy of the therapeutic effects of Lactobacillus and α-lipoic acid against dimethylnitrosamine-induced liver fibrosis in rats
2014, Journal of Genetic Engineering and BiotechnologyCitation Excerpt :Thus, probiotics may be an avenue to provide a safe, cost effective, and natural approach to add a barrier against microbial infection [31,56]. α-Lipoic acid (ALA) is an eight-carbon disulfide compound [62] and functions as a natural cofactor in pyruvate and α-keto dehydrogenase complexes [3,40]. ALA and its reduced form, dihydrolipoic acid, act as potent antioxidants [53] that scavenge free radicals [3,36].
Lipoic acid analogs with enhanced pharmacological activity
2014, Bioorganic and Medicinal ChemistryProtective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline
2013, Brain ResearchCitation Excerpt :Furthermore, several groups have already reported that serum-deprivation produced ROS in RGC-5 cells (Jung et al., 2008; Nakajima et al., 2009). Accumulating evidence suggests that R-LA has neuroprotective effects in models of brain ischemia (Wolz and Krieglstein, 1996; Clark et al., 2001) and neurodegeneration (Karunakaran et al., 2007; Siedlak et al., 2009), such as Alzheimer's disease (Lovell et al., 2003) and Parkinson's disease (Bharat et al., 2002). It has been reported that R-LA-mediated neuroprotection required a pretreatment time of hours to days (Bharat et al., 2002; Wang et al., 2010; Yamada et al., 2011), raising the possibility that this time span may be required for working this antioxidant signaling.