Preferential vasoconstrictor properties of acetazolamide on the arteries of the choroid plexus

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Abstract

Vasoconstrictor potencies of acetazolamide and 1-norepinephrine (1-NE) were determined on isolated, arterially perfused choroid plexus, spleen, stomach, kidney and hind limb of the rat. Acetazolamide produced vasoconstriction of the arteries of the choroid plexus, but had no effect on the otgans studied. 1-NE, however, produced vasoconstriction in all preparations. The possible implication of these findings on spinal fluid formation is mentioned.

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International Exchange Fellow.

national Cancer Institute, Laboratory of Chemical Pharmacology, National Institutes of Health.

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