Elsevier

Life Sciences

Volume 37, Issue 6, 12 August 1985, Pages 567-573
Life Sciences

First pass metabolism of ethanol - A gastrointestinal barrier against the systematic toxicity of ethanol

https://doi.org/10.1016/0024-3205(85)90470-9Get rights and content

Abstract

Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This “first pass” metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of ethanol. This barrier can be overcome by large doses of ethanol. Its efficiency is also reduced by a decrease in gastric alcohol dehydrogenase (ADH) activity secondary to chronic alcohol consumption.

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