Structure-activity relationships among 5-methoxy-N:N-dimethyltryptamine, 4-hydroxy-N:N-dimethyltryptamine (psilocin) and other substituted tryptamines☆
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Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Furthermore, bufotenine does not substitute for either LSD [Helsley et al., 1998] or psilocybin [Winter et al., 2007] in rats trained with the latter drugs. These results are plausibly explained on the basis of low lipid solubility [Gessner et al., 1968] with the consequence that only small amounts of bufotenine are found in rat brain following IV administration [Sanders and Bush, 1967]. Furthermore, the hypothermic effects of bufotenine are antagonized by xylamidine, a peripherally acting serotonergic antagonist [Winter, 1972].
Psilocybin-induced stimulus control in the rat
2007, Pharmacology Biochemistry and BehaviorAn ethnopharmacological examination ofVirola elongata bark: A South American arrow poison
1984, Journal of EthnopharmacologyDOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines
1983, European Journal of Pharmacology
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This research was supported by United States Public Health Service Grant 1 RO1 MH-07575, from the National Institute of Mental Health.
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Present address Clarke Institute of Psychiatry, Toronto, Ontario
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