Reduction of primary postoperative adhesion formation under calcium channel blockade in the rabbit☆
References (16)
- et al.
The nature of posttuboplasty pelvic adhesions as determined by early and late laparoscopy
Fertil. Steril.
(1984) - et al.
The use of calcium channel blockade for prevention of post-operative adhesion formation
Fertil. Steril.
(1988) - et al.
Verapamil depresses the synthesis of lipogenase products by hypoxic cardiac rat fibroblasts in culture
Biochem. Pharmacol.
(1986) - et al.
Calcium channel blocker diltiazem inhibits platelet activation and stimulates vascular prostacyclin release
Amer. J. Med. Sci.
(1986) - et al.
The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes
Biochem. Pharmacol.
(1984) Prevention and management of peritoneal adhesions
Fertil. Steril.
(1984)- et al.
The use of diltiazem for prevention of postoperative adhesion formation
J. Reprod. Med.
(1988) - et al.
Reduction of adhesion formation with perioperative verapamil treatment
Cited by (37)
Therapeutics
2022, Textbook of Rabbit Medicine, Third EditionRabbits
2022, Carpenter's Exotic Animal Formulary, Sixth EditionRabbits
2018, Exotic Animal Formulary: Fifth EditionLarge bowel resection and anastomosis in a domestic rabbit following obstruction
2017, Journal of Exotic Pet MedicineCitation Excerpt :Rabbits are known to be prone to the formation of adhesions after surgical procedures.9 Medications that have been studied to decrease adhesion formation include verapamil, hyaluronic acid solutions, sodium carboxymethyl cellulose, and chondroitin sulfate.12,13 Since the patient in this report already had an identified adhesion, reducing postoperative adhesions was considered to be a necessity.
Fucoidan film safely inhibits surgical adhesions in a rat model
2011, Journal of Surgical ResearchCitation Excerpt :As the initial response to injury involves the inflammatory cascade, corticosteroids [11] and non-steroidal anti-inflammatory drugs (NSAIDs) were among the earliest agents examined [12], as were anticoagulants such as heparin [13], and fibrinolytics such as streptokinase [14]. Recently the list of potential therapeutic agents has increased considerably, fueled by new insights into the biochemistry of adhesion formation, and has included growth factor inhibitors and modulators [15], tissue plasminogen activator [16], aromatase inhibitors [17], statins [18], angiotensin converting enzyme-inhibitors [19], extracellular matrix remodelers [20], antibiotics [21], platelet activating factor antagonists [22], hormones and hormone agonists [23, 24], calcium channel blockers [25], oxygen free radical inhibitors [26], and antiproliferative agents [27, 28]. Although some of these drugs demonstrated initial efficacy in a limited number of animal models, none has shown adhesion-reduction benefits in the clinical setting, and many have exhibited deleterious side effects.
Prevention of postoperative peritoneal adhesions
2010, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :Aloe Vera gel [78] has considerably decreased postoperative adhesions. Experimental animal studies with colchicine [79], medroxyprogesterone acetate [80], calcium channel blockers [81], phosphatidylcholine [82], vitamin E [83], d-penicillamine [84], methylene blue [85], pentoxifylline [86], statins [87], and epidermal growth factor [88], show reduction in adhesion formation. Their efficacy in humans remains to be seen with further research.
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Supported by grants from the medical research committee of Valley Medical Center of Fresno and by Fresno Community Hospital, Fresno, California.