Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems
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2020, Clinics in Plastic SurgeryCitation Excerpt :Despite its classification, cyclobenzaprine does not act on skeletal muscle. It is a centrally acting medication that is thought to act at the brainstem level on the locus ceruleus, decreasing the activity of serotonergic descending neurons, thus decreasing muscle tone.49,50 The effect on the locus ceruleus may help to explain the sedating qualities of the medication.
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2011, Journal of the American Dental AssociationCitation Excerpt :Cyclobenzaprine also may increase the effects of alcohol, barbiturate agents and other drugs that depress the central nervous system.32 The side effects reported in the literature are drowsiness, dry mouth, lethargy, tachycardia, agitation, hypertension and hypotension.32,33 However, the results of multicenter studies have shown that the side effects and toxicity of cyclobenzaprine at doses of lower than 1 g do not produce life-threatening cardiac, respiratory or neurological effects.30
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