Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation
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Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats
2019, Pharmacological ResearchCitation Excerpt :Further studies are necessary to elucidate the actual mechanism by which MDMA induces low density of SERT. MDMA has been well demonstrated to induce an immediate elevation in plasma corticosterone or cortisol level [26,27,43,44], likely resulting from the release of 5-HT and activation of 5-HT2 receptor on hypothalamic neurons that regulate pituitary-adrenocortical function [45–47]. In agreement with previous studies, our results revealed that MDMA induced significant increase in plasma concentration of corticosterone.
Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[<sup>18</sup>F]-ADAM/small-animal PET study
2016, European NeuropsychopharmacologyCitation Excerpt :However, our data showed that RSV afforded negligible protection against MDMA-induced loss of SERT in the frontal cortex (Figure 4B). MDMA has been well demonstrated to induce an immediate elevation in plasma corticosterone or cortisol level (Downey et al., 2015; Johnson and Yamamoto, 2010; Parrott et al., 2013; Parrott et al., 2014), likely resulting from the release of 5-HT and activation of 5-HT2 receptor on hypothalamic neurons that regulate pituitary-adrenocortical function (Fuller, 1981; Holmes et al., 1982; Koenig et al., 1987). The current data confirmed these previous findings (Figure 3C), although this MDMA-induced effect was ceased upon drug withdrawn.
Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: The role of corticosterone
2009, NeuroscienceCitation Excerpt :Therefore, the enhancement of MDMA-induced hyperthermia after CUS may be mediated by a chronic stress-induced and CORT-dependent increase in 5-HT2A receptor density or function. Hypothalamic 5-HT2A receptors are also involved in for CORT regulation (Koenig et al., 1987), although we found enhanced MDMA-induced hyperthermia without a potentiation of CORT. This may be the result of a differential regulation of hyperthermia and CORT by 5HT2A receptors in subregions of the hypothalamus.
Interaction between serotonin 5-HT1A receptors and β-endorphins modulates antidepressant response
2008, Progress in Neuro-Psychopharmacology and Biological PsychiatryIndoloxypropanolamine analogues as 5-HT<inf>1A</inf> receptor antagonists
2007, Bioorganic and Medicinal Chemistry LettersHormonal and temperature responses to flesinoxan in normal volunteers: An antagonist study
2004, European Neuropsychopharmacology
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Present address: Neurology Service, Massachusetts General Hospital, 34 Fruit Street, Boston, MA 02114, U.S.A.