Aberrant casein kinase II in Alzheimer's disease
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2021, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Increased levels of CK2 have been detected in the hippocampus and temporal cortex of AD patients compared to non-demented controls [35]. AD hippocampal neurons bearing neurofibrillary tangles (NFT) stain very strongly for CK2 [85–87]. Certainly, the known importance of CK2 and its reported overabundance in the hippocampus could contribute to the vulnerability of this brain region in AD.
Regulation of HSF1 protein stabilization: An updated review
2018, European Journal of PharmacologyCitation Excerpt :According to the study by Jiang et al., the HSF1 protein decrease in AD brains is associated with the decrease in HSF1 mRNA expression (Jiang et al., 2013), which is different from that observed in other neurodegenerative disease models, such as PD and ALS. The contribution of protein degradation should also be considered, as CK2, a previously reported kinase responsible for the phosphorylation-dependent HSF1 degradation (Gomez-Pastor et al., 2017), is found to be implicated in the pathogenesis of AD (Masliah et al., 1992; Iimoto et al., 1990; Perez et al., 2011). For example, the altered CK2 has been shown to promote AD phenotypes via phosphorylation of tau (Masliah et al., 1992).
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