Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex
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Trigeminal neuralgia and persistent idiopathic facial pain (atypical facial pain)
2022, Disease-a-MonthCitation Excerpt :Lamotrigine is a sodium channel blocking AED, which may suppress the release of glutamate and aspartate, both excitatory neurotransmitters. The drug is unique, having little in common with other sodium channel blocking AEDs197,198 While in 2008, a study found that Lamotrigine was effective in treating a number of pain and neuropathic pain syndromes including central neuropathic pain, trigeminal neuralgia, trigeminal neuralgia in multiple sclerosis, pain in multiple sclerosis, SUNCT, cluster headache, glossopharyngeal neuralgia, neuropathic pain, allodynia, neuralgia after nerve resection, postherpetic neuralgia, and HIV associated neuropathic.199
Recent advancement in the discovery and development of anti-epileptic biomolecules: An insight into structure activity relationship and Docking
2020, European Journal of Pharmaceutical SciencesThe anticonvulsant lamotrigine enhances I <inf>h</inf> in layer 2/3 neocortical pyramidal neurons of patients with pharmacoresistant epilepsy
2019, NeuropharmacologyCitation Excerpt :Lamotrigine (LTG, 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine) is currently used clinically as anticonvulsant drug in the treatment of epilepsy, i.e. to treat focal seizures, primary and secondary tonic-clonic seizures, as well as seizures associated with Lennox-Gastaut syndrome. LTG shares few side effects with traditional anticonvulsants, emphasizing its unique properties (Lees and Leach, 1993). In line with other anticonvulsants, LTG has shown potential capacity as a mood stabilizer, making it an adjunct in treating depression (Barbosa et al., 2003).
Electrochemical measurement of lamotrigine using boron-doped diamond electrodes
2018, Electrochimica Acta
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Present address: Academic Department of Anaesthetics, St. Mary's Hospital Medical School, QEQM Wing, Paddington, London, W2 1NY.