Original articleRelationship between smooth pursuit eye-tracking and cognitive performance in schizophrenia
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Cited by (33)
Amphetamine-induced alteration to gaze parameters: A novel conceptual pathway and implications for naturalistic behavior
2021, Progress in NeurobiologyCitation Excerpt :Indeed, converging evidence shows that saccadic generation and execution is closely related to component aspects of cognitive control involved in the preparation and execution of visually guided behaviours, such as attention (Ridderinkhof et al., 2004). Impairment in these processes is routinely observed in conditions of DA deficiency (such as Parkinson’s Disease) and hyperactivity (schizophrenia), and alternations are observed to correlate with degree of deficits in frontal lobe function (particularly attentional capacity) (Friedman et al., 1995). Together, these findings support the neuromodulatory effect of DA in visual attentional disturbances and provides additional evidence for a framework in mapping amphetamine-induced changes as expressed by oculomotor control.
Predictive pursuit association with deficits in working memory in psychosis
2012, Biological PsychiatryComparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: Examining evidence for the schizo-obsessive subtype
2012, Schizophrenia ResearchCitation Excerpt :In a recent review of eye movement studies in OCD, the authors concluded that pursuit deficits in this clinical population “are much less robust and systematic” than in schizophrenia, and speculated that this difference may be due to the greater involvement of dorsolateral prefrontal cortex in schizophrenia vs. orbitofrontal prefrontal cortex in OCD (Jaafari et al., 2011). The superiority of the qualitative rating of eye tracking in distinguishing OCD-co-morbid schizophrenia patients from non-OCD patients is consistent with other reports that this measure discriminates patients and relatives from controls better than specific quantitative measures (e.g., Friedman et al., 1995; Keefe et al., 1997; Levy et al., 2000). A recent meta-analysis of eye tracking dysfunction in schizophrenia quantified the results of studies that used specific quantitative measures of pursuit performance and global measures (O'Driscoll and Callahan, 2008).
Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives
2009, Psychiatry ResearchCitation Excerpt :The eye movement tasks that are thought to be of most relevance in schizophrenia are the smooth pursuit and antisaccade tasks. Some studies have found correlations between smooth pursuit and neuropsychological measures (executive function, working memory) (Bartfai et al.,1985; Katsanis and Iacono,1991; Litman et al., 1991; Park and Holzman, 1993; Grawe and Levander, 1995; Snitz et al., 1999; Iloreta et al., 2005) although others have not (Tien et al., 1996; Hutton et al., 2004) and another (Friedman et al., 1995) gave inconclusive results. Similarly, most studies that have investigated the relationship between antisaccade errors and neuropsychological measures in schizophrenic patients have observed significant correlations (Rosse et al., 1993; Crawford et al., 1995; Tien et al., 1996; Radant et al., 1997; Karoumi et al., 1998; Nieman et al., 2000; Gooding and Tallent, 2001; Levy et al., 2004; Hutton et al., 2004), although again, there have been exceptions (Snitz et al., 1999).
Smooth pursuit in schizophrenia: A meta-analytic review of research since 1993
2008, Brain and CognitionCitation Excerpt :In fact there is a growing literature in this area. Some of the studies reviewed here included comparisons to other psychiatric disorders, including affective disorders (Flechtner, Steinacher, Sauer, & Mackert, 1997; Flechtner, Steinacher, Sauer, & Mackert, 2002; Friedman, Kenny, Jesberger, Choy, & Meltzer, 1995; Kathmann, Hochrein, Uwer, & Bondy, 2003; Lencer et al., 2004;), obsessive compulsive disorder (Farber, Clementz, & Swerdlow, 1997) attention deficit disorder (Jacobsen et al., 1996; Ross, Olincy, Harris, Sullivan, & Radant, 2000) and alcohol dependence (Kathmann, Wagner, Rendtorff, Schöchlin, & Engel, 1995). These studies and others have used other psychiatric disorders as pathological control groups for schizophrenia, although studies have also been done of pursuit in depression (Malaspina et al., 1994), and obsessive compulsive disorder (Clementz, Farber, Lam, & Swerdlow, 1996; Pallanti et al., 1996) in their own right.
Cognitive dysfunctions in medicated and unmedicated patients with recent-onset schizophrenia
2005, Journal of Psychiatric Research
Supported in part by grants to Dr. Friedman (USPHS, MH 47574 and the Scottish Rite Schizophrenia Research Program), and to Dr. Meltzer (MH 41684, MH 41594, John Pascal Sawyer Foundation, Mr. and Mrs. Milton Maltz and the Laureate Foundation).