Response of sphingolipid hydrolases in spleen and liver to increased erythrocytorhexis

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Abstract

The injection of phenylhydrazine, zymosan, and human erythrocyte stroma caused an increase in the specific activities of various hydrolytic enzymes in rat spleen and liver tissues.

The activity of spleen glucocerebrosidase and sphingomyelinase was particularly augmented by the injection of phenylhydrazine whereas the increases obtained with zymosan were not statistically significant.

The injection of red-cell stroma brought about a significant increase in the activity of these enzymes; the injection of lipid-extracted stroma had no effect.

The injection of partially purified stromal sphingolipids consisting mainly of globoside and sphingomyelin caused an increase in the activity of glucocerebrosidase and sphingomyelinase in liver but not in spleen.

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