A novel method for encapsulation of macromolecules in liposomes
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Liposomes: structure, composition, types, and clinical applications
2022, HeliyonCitation Excerpt :First, the dehydration step to evaporate water under nitrogen to create multilayered film entrapping the drug molecules. Then, a hydration step to form large vesicles encapsulating the drug molecules [50, 163]. This method is simple but with high heterogeneity of the liposomes sizes [164].
Liposome composition in drug delivery design, synthesis, characterization, and clinical application
2021, Advanced Drug Delivery ReviewsCitation Excerpt :Dehydration-rehydration is used to synthesize LUVs without the use of organic solvents or detergents. In this method, liposomes are made by dispersing lipids and amphihilic molecules at low concentrations directly into an aqueous solution followed by sonication [32]. The drug to be encapsulated may be added to the aqueous solution and mixed with the formulated vesicles.
Laminin-derived peptides: Applications in drug delivery systems for targeting
2019, Pharmacology and TherapeuticsCitation Excerpt :Therefore, we sought to prepare AG73-modified liposomes encapsulated with doxorubicin (Dox) (AG73–Dox), a representative anticancer drug. Dox-encapsulated liposomes (Dox–PEG) containing phospholipids, such as 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), DSPE–PEG2000–OMe, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (DSPE–PEG2000–Mal), were prepared using both a rehydration method (Shew and Deamer, 1985) and a remote loading method with a pH gradient (Dos Santos et al., 2004). For coupling, AG73 was added to the Dox-encapsulated liposomes, and the cysteine of the Cys–AG73 was conjugated with the Mal of the Dox–PEG using a thioether bond (Negishi et al., 2011).
Lipid nanocarriers for the loading of polyphenols – A comprehensive review
2018, Advances in Colloid and Interface Science