Case reportCarbon dioxide prevents pulmonary overcirculation in hypoplastic left heart syndrome
References (3)
- et al.
Effect of pH and Pco2 on pulmonary and systemic hemodynamics after surgery in children with congenital heart disease and pulmonary hypertension
J Pediatr
(1988)
Cited by (110)
Non-pharmacological management of a hemodynamically significant patent ductus arteriosus
2018, Seminars in Fetal and Neonatal MedicineCitation Excerpt :In addition, a single-ventricle neonatal piglet model showed that PVR increased in direct correlation with the carbon dioxide content of the inspired gas administered [34]. Inspired carbon dioxide has been used previously for neonatal patients with hypoplastic left-heart syndrome as an intervention to limit pulmonary blood flow during the perioperative period [28,35]. Indeed, a 2001 study reported that inspired carbon dioxide post Norwood procedure improved systemic oxygen delivery [36].
Hypoplastic left heart syndrome: Current considerations and expectations
2012, Journal of the American College of CardiologyCitation Excerpt :Because venous oxygen measures were difficult to obtain, the variability in systemic blood flow was a theoretic concept (84) not visible at the bedside, and clinical management focused on preventing a rise in SaO2. Manipulation of inspired gas mixtures to control PVR, particularly inspired carbon dioxide (CO2), was reported to increase stability after Norwood palliation for HLHS (85–87). Both reduced fraction of inspired O2 and inspired CO2 will acutely lower SaO2, but only hypercarbia will improve systemic oxygen delivery and cerebral oxygenation (30,88,89).
Mechanical Ventilation and Respiratory Care
2011, Pediatric Critical Care: Expert Consult Premium EditionMechanical Ventilation and Respiratory Care
2011, Pediatric Critical CareNeonatal surgical reconstruction and peri-operative care for hypoplastic left heart syndrome: Current strategies
2011, Cardiology in the Young