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A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS2/ZnS quantum dots

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Abstract

A fluorescent sensing material based on the ternary core–shell quantum dots with outstanding optical properties and a bio-inspired molecularly imprinted polymer (MIP) as a recognition element has been prepared for selective detection of rifampicin (RFP). Firstly, AgInS2/ZnS core/shell quantum dots (ZAIS QDs) were prepared by a hydrothermal process. Then, the fluorescent sensor was prepared by coating these QDs by a dopamine-based MIP layer. The fluorescence of MIP@ZAIS QDs was quenched by RFP probably due to the photoinduced electron transfer process. The quenching constant was much higher for MIP@ZAIS QDs than the non-imprinted polymer@QDs, indicating that MIP@ZAIS QDs could selectively recognize RFP. Under the optimized conditions, the sensor had a good linear relationship at the RFP concentration range of 5.0 to 300 nM and the limit of detection was 1.25 nM. The respond time of the MIP@ZAIS QDs was 5 min, and the imprinting factor was 6.3. It also showed good recoveries ranging from 98 to 101%, for analysis of human plasma samples. The method is simple and effective for the detection of RFP and offers a practical application for the rapid analysis of human plasma samples.

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Authors and Affiliations

  1. Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Farzaneh Rasoulzadeh

  2. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Farzaneh Rasoulzadeh

  3. Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166616471, Iran

    Mohammad Amjadi

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Correspondence to Farzaneh Rasoulzadeh.

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Rasoulzadeh, F., Amjadi, M. A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS2/ZnS quantum dots. ANAL. SCI. (2024). https://doi.org/10.1007/s44211-024-00512-y

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