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Intrathoracic Extension of a Giant Cell Tumour of the Medial End of Clavicle: A Case Report with Review of Literature

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Abstract

Introduction

The clavicle is a very rare site for primary bone tumours, and Giant cell tumours of the clavicle are even rarer. Very few cases have been reported in the literature.

Method

The authors report a rare presentation of intrathoracic extension of a giant cell tumour of the medial end of the clavicle, in an 18-year-old female. The patient had painful swelling at the sternal end of the clavicle associated with a painful shoulder range of motion. Complete resection of the mass was done, preserving the lateral half of the clavicle.

Result and Discussion

At a 3-year follow-up, the patient has a good clinical outcome with no signs of recurrence. Being a very rare entity, no clear guidelines are available for the management of GCT of Clavicle. Adequate resection of the tumour mass remains the mainstay of treatment and has shown promising results. Denosumab has been proved to be effective in some studies, but the high cost of treatment is a major limitation in the Indian scenario.

Conclusion

Resection of the tumour mass with partial cleidectomy provided good results in this patient.

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References

  1. World Health Organization WHO, Fletcher, C., Bridge, J. A., Hogendoorn, P. C. W., & Mertens, F. (ed.). (2013). WHO classification of tumours of soft tissue and bone: WHO classification of tumours (4th ed., Vol. 5, p. 468). World Health Organization.

  2. Mavrogenis, A. F., Igoumenou, V. G., Megaloikonomos, P. D., Panagopoulos, G. N., Papagelopoulos, P. J., & Soucacos, P. N. (2017). Giant cell tumor of bone revisited. SICOT Journal, 3, 54. https://doi.org/10.1051/sicotj/2017041.

    Article  Google Scholar 

  3. Raskin, K. A., Schwab, J. H., Mankin, H. J., Springfield, D. S., & Hornicek, F. J. (2013). Giant celltumor of bone. Journal of American Academy of Orthopaedic Surgeons, 21, 118–126.

    Article  Google Scholar 

  4. Dahlin, D. C., & Krishnan Unni, K. (1986). Bone tumors: general aspects and data on 8,547 cases. Springfield, IL: Charles C. Thomas Publisher.

    Google Scholar 

  5. Klein, M. J., Lusskin, R., Becker, M. H., & Antopol, S. C. (1979). Osteoid osteoma of the clavicle. Clinical Orthopaedics, 143, 162.

    Google Scholar 

  6. Jaffe, H. L., Lichtenstein, L., & Portis, R. B. (1940). Giant cell tumor of the bone: Its pathological appearance, grading, supposed variant and treatment. Archives of Pathology, 30, 993–1031.

    Google Scholar 

  7. Constant, C. R., & Murley, A. H. (1987). A clinical method of functional assessment of the shoulder. Clinical Orthopaedics & Related Research, 214, 160–164.

    Article  Google Scholar 

  8. Japanese Orthopaedic Association. (1994). Scoring system for cervical myelopathy. Journal of Japanese Orthopaedic Association, 68, 490–503.

    Google Scholar 

  9. Cooper, A. P., & Travers, B. (1818). Surgical essays. Cox.

    Google Scholar 

  10. Campanacci, M., Baldini, N., Boriani, S., & Sudanese, A. (1987). Giant-cell tumor of bone. Journal of Bone and Joint Surgery American, 69, 106–114.

    Article  CAS  Google Scholar 

  11. Murphey, M. D., Nomikos, G. C., Flemming, D. J., et al. (2001). From the archives of AFIP: Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologic-pathologic correlation. Radiographics, 21, 1283–1309.

    Article  CAS  Google Scholar 

  12. Davies, A. M., Sundaram, M., Steven, L., & James, J. (2009). Imaging of bone tumors and tumor-like lesions: techniques and applications. Heidelberg: Springer-Verlag.

    Book  Google Scholar 

  13. Resnick, D. (1995). Diagnosis of bone and joint disorders (3rd ed.). Saunders.

    Google Scholar 

  14. Unni, K. K., & Dahlin, D. C. (1996). Dahlin’s bone tumors: general aspects and data on 11,087 cases (5th ed.). Lippincott-Raven: Philadelphia.

    Google Scholar 

  15. Balke, M., Schremper, L., Gebert, C., Ahrens, H., Streitbuerger, A., Koehler, G., Hardes, J., & Gosheger, G. (2008). Giant cell tumor of bone: Treatment and outcome of 214 cases. Journal of Cancer Research and Clinical Oncology, 134(9), 969–978.

    Article  CAS  Google Scholar 

  16. Wood, V. E. (1986). The results of total claviculectomy. Clinical Orthopaedics and Related Research, 207, 186–190.

    Article  Google Scholar 

  17. Krishnan, S. G., Schiffern, S. C., Pennington, S. D., Rimlawi, M., & Burkhead, W. Z. Jr. (2007). Functional outcomes after total claviculectomy as a salvage procedure. A series of six cases. Journal of Bone and Joint Surgery American, 89(6), 1215–1219. https://doi.org/10.2106/JBJS.E.01436.

    Article  Google Scholar 

  18. Rockwood, C., & Wirth, M. (1992). Don’t throw away the clavicle. Orthopaedic Translation, 16, 763.

    Google Scholar 

  19. Thornley, P., Habib, A., Bozzo, A., Evaniew, N., & Ghert, M. (2017). The role of denosumab in the modern treatment of giant cell tumor of bone. JBJS Reviews, 5(4), e4. https://doi.org/10.2106/JBJS.RVW.16.00072.

    Article  PubMed  Google Scholar 

  20. Errani, C., Tsukamoto, S., Leone, G., Righi, A., Akahane, M., Tanaka, Y., & Donati, D. M. (2018). Denosumab may increase the risk of local recurrence in patients with giant-cell tumor of bone treated with curettage. The Journal of Bone and Joint Surgery, 100(6), 496–504.

    Article  Google Scholar 

  21. Singh, V. A., & Puri, A. (2020). The current standing on the use of Denosumab in giant cell tumour of the bone. Journal of Orthopaedic Surgery, 28(3), 2309499020979750.

    PubMed  Google Scholar 

  22. Friedman, B., Nerubay, J., Lokiec, F., Horoszowski, H., & Yelin, A. (1989). Giant cell tumour occurring in the clavicle: A report of two cases. Respiratory Medicine, 83(2), 145–148.

    Article  CAS  Google Scholar 

  23. Beg, M. H., Ansari, M. M., Uddin, R., & Nairn, M. (1989). A case of giant-cell tumor of the clavicle. Acta Orthopaedica Scandinavica, 60(1), 122–122.

    Article  CAS  Google Scholar 

  24. Bajpai, J., Saini, S., Bajpai, A., & Khera, R. (2013). Rare presentation of giant cell tumor of bone in the lateral end of the clavicle. American Journal of Case Reports, 5(14), 235–237.

    Google Scholar 

  25. Nagano, S., Tsuchimochi, T., Yokouchi, M., Setoguchi, T., Sasaki, H., Shimada, H., Nakamura, S., Ishidou, Y., Yamamoto, T., & Komiya, S. (2015). Giant cell tumor of the clavicle: Report of a case in a rare location with consideration of surgical method. BMC Musculoskeletal Disorders, 12(16), 142.

    Article  Google Scholar 

  26. Khatri, K., Singh, J., Kalia, A., & Dahuja, A. (2016). Giant cell tumour of clavicle: Occurrence of a common tumour in a rare location. International Journal of Surgery Case Reports, 29, 51–55.

    Article  Google Scholar 

  27. Akinsulire, A. T., Badmus, O. O., & Giwa, S. O. (2017). Giant cell tumour of the clavicle: A rare presentation of a locally aggressive tumour. Nigerian Postgraduate Medical Journal, 24(4), 250–253.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedics, Grant Medical College and Sir J.J. Group of Hospitals, Byculla, Mumbai, Maharashtra, India

    Shaswat Mishra, Manish Jain, Sandeep Gavhale, Sagar Bansal, Sanjeev Ghildiyal & Mitali Mokashi

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  1. Shaswat Mishra
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  2. Manish Jain
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  3. Sandeep Gavhale
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  4. Sagar Bansal
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  5. Sanjeev Ghildiyal
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  6. Mitali Mokashi
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Correspondence to Shaswat Mishra.

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Mishra, S., Jain, M., Gavhale, S. et al. Intrathoracic Extension of a Giant Cell Tumour of the Medial End of Clavicle: A Case Report with Review of Literature. JOIO 56, 1834–1840 (2022). https://doi.org/10.1007/s43465-022-00726-0

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  • DOI: https://doi.org/10.1007/s43465-022-00726-0

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