Abstract
Leishmaniasis consists of a group of neglected diseases, which affect millions of people worldwide. First- and second-line chemotherapies, which present high toxicity and variable efficacy, have been available for decades leading to the appearance of resistance. Globally, volatile oils have received much attention due to their increase use as effective bioactive compounds in folk medicine. They have been employed against Leishmania parasites with a positive impact in the treatment of this neglected disease. In this review, the leishmanicidal activity of volatile oils and their isolates have been described as promising novel candidate molecules for the development of leishmanicidal drugs. The purpose of this review is to critically discuss several works published between 2000 and 2020 that have described the utilization of volatile oils and some of their active principles from diverse plant sources against different species of Leishmania.
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The authors are grateful to Dr. Rogelio Pereda-Miranda (Universidade Nacional Autónoma do México), editor-in-chief of the Brazilian Journal of Pharmacognosy, for his suggestions to improve the review quality. Also, thanks are given to Dr. Marco Andre Alves de Sousa for his technical support.
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The authors were financially supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, and Conselho Nacional de Desenvolvimento Científico e Tecnológico.
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MF, RCS, DR, DCS, HLMG, and ACS: selection of articles to compose the review; writing and reviewing. PF, DSAC, and LHPS: supervision, conceptualization, resources, writing, review, and editing. All authors read and approved the final manuscript.
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This article is part of a Special Issue to celebrate the 35th anniversary of the Brazilian Journal of Pharmacognosy
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Fampa, P., Florencio, M., Santana, R.C. et al. Anti-Leishmania Effects of Volatile Oils and Their Isolates. Rev. Bras. Farmacogn. 31, 561–578 (2021). https://doi.org/10.1007/s43450-021-00146-5
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DOI: https://doi.org/10.1007/s43450-021-00146-5