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Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome

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Abstract

This study is aimed at evaluating the correlation between the skeletal muscle mass index (SMI) of different body parts and hyperuricemia in females with polycystic ovary syndrome (PCOS), thus, providing scientific guidance on lifestyle self-management for patients with PCOS. The cross-sectional study included 171 patients with PCOS, which were divided into two distinct sub-groups based on the presence or absence of hyperuricemia. Anthropometric and serological characteristics of the population with PCOS focusing on skeletal muscle mass were conducted. PCOS patients with hyperuricemia had significantly greater SMI in different body parts. Further binary logistic regression analysis revealed that SMI of the bilateral lower limbs was positively associated with hyperuricemia with an adjusted odds ratio (95% confidence interval) of 1.235 (1.103 − 1.384), p < 0.001. The optimal cut-off value of SMI of the bilateral lower limbs in predicting hyperuricemia was 5.11 (Youden index = 0.490). Combined with the mean value of SMI in the bilateral upper limbs, the safe range of SMI of the bilateral lower limbs in patients with PCOS was calculated as 3.64 − 5.11, with the sensitivity and negative predictive values being 83.9% and 65.1%, respectively. Excessively increased SMI of the bilateral lower limbs was correlated with hyperuricemia in patients with PCOS.

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Code Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Data Availability

The data are available from the corresponding author on reasonable request.

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Acknowledgements

The authors are thankful to the Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, for providing facilities to carry out our research work. We also thank the many women who participated in the study.

Funding

The study was supported by the Tianjin Municipal Health Committee (grant no. ZC20005) and the National Natural Science Foundation of China (grant no. 82171629).

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, He Ping District, Tianjin, People’s Republic of China

    Xiaoyan Li, Wenxuan Wu, Xue Li, Hao Wu, Xiang Wang, Wenyan Tian & Huiying Zhang

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  1. Xiaoyan Li
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  2. Wenxuan Wu
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  3. Xue Li
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  4. Hao Wu
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  7. Huiying Zhang
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Correspondence to Wenyan Tian or Huiying Zhang.

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Ethics Approval

The study was approved by the Ethical Ethics Committee of Tianjin Medical University General Hospital (IRB number: IRB2022-WZ-054).

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Written informed consent was obtained from individual or guardian participants.

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Li, X., Wu, W., Li, X. et al. Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome. Reprod. Sci. 30, 2758–2766 (2023). https://doi.org/10.1007/s43032-023-01214-y

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