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Overview of the risks of Staphylococcus aureus infections and their control by bacteriophages and bacteriophage-encoded products

  • Clinical Microbiology - Review
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Abstract

Staphylococcus aureus is the leading cause of secondary infections in hospitals and a challenging pathogen in food industries. Decades after it was first reported, β-lactam-resistant S. aureus remains a subject of intense research owing to the ever-increasing issue of drug resistance. S. aureus bacteriophages (phages) or their encoded products are considered an alternative to antibiotics as they have been shown to be effective in treating some S. aureus-associated infections. In this review, we present a concise collection of the literature on the pathogenic potential of S. aureus and examine the prospects of using S. aureus phages and their encoded products as antimicrobials.

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Acknowledgements

We are thankful to Environmental Virology Cell, CSIR-NEERI, Nagpur and Director CSIR-NEERI for providing the research facility and infrastructure. Financial assistance to Akanksha Rai in form of fellowship from the University Grants Commission (UGC), India is gratefully acknowledged. We thank Traci Raley, MS, ELS, for editing a draft of this manuscript.

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Financial assistance as fellowship from the University Grants Commission (UGC), India.

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  1. Environmental Virology Cell, Council of Scientific and Industrial Research-National Environmental Engineering Research Institute (CSIR NEERI), Nehru Marg, Nagpur, 440020, Maharashtra, India

    Akanksha Rai & Krishna Khairnar

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India

    Akanksha Rai & Krishna Khairnar

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Conceptualization: Krishna Khairnar and Akanksha Rai; Writing and original draft preparation: Akanksha Rai; Writing, reviewing, and editing: Akanksha Rai and Krishna Khairnar.

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Rai, A., Khairnar, K. Overview of the risks of Staphylococcus aureus infections and their control by bacteriophages and bacteriophage-encoded products. Braz J Microbiol 52, 2031–2042 (2021). https://doi.org/10.1007/s42770-021-00566-4

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