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Novel Insights into the Characteristics of Poorly Differentiated Schneiderian Carcinoma: a Case Report

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Abstract

Low-grade papillary Schneiderian carcinoma is a poorly characterized disease in terms of molecular characteristics and treatment success. Here, we describe a case of poorly differentiated Schneiderian carcinoma with both p53 and p63 positive tumor and overexpression of miR-21that was successfully treated with a single intervention of right jaw hemiresection.

A 61-year-old patient presented with nasal obstruction presented into the clinic. The CT imaging showed the presence of a Schneiderian papilloma in the posterior wall of the right maxillary sinus, with invasion to the right infra-temporal fissure. The histopathological and immunohistopathological revealed that the tumor belonged to the low-grade papillary Schneiderian carcinoma, an aggressive type of head and neck tumor. The decision was made to do a right jaw hemiresection. The resected specimen exhibit epithelial cells that had the growth pattern of inverted papilloma. The CT scanning done during post-operative follow-up found soft tissue in the anterior and lateral maxillary, but the biopsy revealed no presence of tumoral cells, only local inflammation. The immunohistochemistry analysis showed that the resected tumor tissue was p63+, CK7+, p16+, p53+, and Ki67+. The miRNA RT-PCR analysis on the resected tumor versus adjacent normal tissue revealed that miR-21 is overexpressed in tumor tissue, while miR-34a and miR-16 did not show any difference in expression. Our case description shows that even in case of aggressive Schneiderian papilloma molecular profile, the tumor spread is prevented by extending the surgery margins up to jaw hemiresection.

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Funding

The research was funded by the PCD project entitled: “Stem cell involvement in oncological, oral and maxillofacial pathology” and by the project PNCDI III 2015-2020 “Increasing the performance of scientific research and technology transfer in translational medicine through the formation of a new generation of young researchers”—ECHITAS, no.29PFE/18.10.2018.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania

    Diana Monica Urcan, Florin Onisor & Grigore Baciut

  2. MEDFUTURE-Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu-Hatieganu, Cluj-Napoca, Romania

    Alina-Andreea Zimta & Ioana Berindan-Neagoe

  3. Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

    Oana Zanoaga & Ioana Berindan-Neagoe

  4. Department of Pathological Anatomy, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Clinicilor Street, no 3-5, 400006, Cluj-Napoca, Romania

    Dan Gheban

  5. Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania

    Ioana Berindan-Neagoe

Authors
  1. Diana Monica Urcan
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  2. Alina-Andreea Zimta
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  3. Florin Onisor
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  4. Oana Zanoaga
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  5. Dan Gheban
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  6. Grigore Baciut
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  7. Ioana Berindan-Neagoe
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Correspondence to Ioana Berindan-Neagoe.

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Urcan, D.M., Zimta, AA., Onisor, F. et al. Novel Insights into the Characteristics of Poorly Differentiated Schneiderian Carcinoma: a Case Report. SN Compr. Clin. Med. 2, 985–991 (2020). https://doi.org/10.1007/s42399-020-00332-x

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