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Recent Advances of DNA Hydrogels in Biomedical Applications

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Abstract

DNA hydrogel is one of DNA-based nanomaterials with unique advantages such as precise self-assembly, programmability, addressability, high stability, excellent biocompatibility and biodegradability, and tunable versatility. These features have greatly promoted the development of DNA hydrogels in various applications, especially molecular diagnostics, biosensing, drug delivery, and cancer therapy. In this review, we briefly review the history of DNA hydrogels, the latest advances of DNA hydrogels in biomedical applications especially in biosensing, drug delivery and cancer therapy, and prospect the key challenges and future directions.

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Fig. 1
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modified from scheme 1 in ref. [63]

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modified from scheme 1 in ref. [69]; lower right, modified from Fig. 1a in ref. [70]

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modified from Fig. 1a in ref. [31]

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Acknowledgements

This work was supported by the National Natural Science of China (31972622), the Fundamental Research Funds for the Central Universities (XDJK2020TJ001 and XDJK2020C049).

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Authors and Affiliations

  1. State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing, 400715, China

    Huai-Qing Chen, Wan Yang, Hua-Wei He & Ye-Jing Wang

  2. College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China

    Hua Zuo

  3. Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing, 400715, China

    Hua-Wei He & Ye-Jing Wang

  4. Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Chongqing, 400715, China

    Hua-Wei He

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  1. Huai-Qing Chen
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  3. Hua Zuo
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  4. Hua-Wei He
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Correspondence to Hua Zuo or Ye-Jing Wang.

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Chen, HQ., Yang, W., Zuo, H. et al. Recent Advances of DNA Hydrogels in Biomedical Applications. J. Anal. Test. 5, 155–164 (2021). https://doi.org/10.1007/s41664-021-00185-w

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