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Enzyme-Responsive Peptide-Based AIE Bioprobes

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Abstract

Enzyme, which exists widely in organisms, has high specificity and high catalytic efficiency for its substrates. The absence, the reduced activity, or the overexpression of enzyme are closely related to the occurrence and development of diseases. Therefore, enzyme is often used as markers for disease detection and treatment. To detect enzyme activity and track drug release, aggregation-induced emission (AIE) bioprobes have been developed because of their excellent photostability and high signal-to-noise ratio (SNR). Among them, peptide-based AIE bioprobes with great biocompatibility and specificity are favored by an increasing number of researchers. Enzymatic hydrolysis of peptide can cause aggregation of AIE molecules and drug release. In this review, enzyme-responsive peptide-based AIE bioprobes used for biomedical application are summarized according to the three aggregation strategies triggered by various reaction between peptide and enzyme, including enzyme-triggered precipitate, enzyme-catalyzed coupling, and enzyme-instructed self-assembly. By giving some representative examples, we discuss how each aggregation strategy detects enzyme activity and treats the diseases under imaging guidance. Finally, we comment on the current problems and future prospects of enzyme-responsive peptide-based AIE bioprobes.

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Acknowledgements

The authors acknowledge financial support from the National Natural Science Foundation of China (21722507, 21525523, 21974128, 21874121) and the Natural Science Foundation of Hubei Province (2019CFA043).

Author information

Authors and Affiliations

  1. Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China

    Juliang Yang, Jiaming Wei, Jing-Jing Hu, Xiaoding Lou & Fan Xia

  2. China National Tobacco Corporation Hunan Branch Logistics Management Office, Changsha, 410004, China

    Fan Luo

  3. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China

    Jun Dai

Authors
  1. Juliang Yang
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  2. Jiaming Wei
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  3. Fan Luo
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  4. Jun Dai
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  5. Jing-Jing Hu
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  6. Xiaoding Lou
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  7. Fan Xia
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Corresponding authors

Correspondence to Jing-Jing Hu or Xiaoding Lou.

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This article is part of the Topical Collection “Aggregation Induced Emission”; edited by Youhong Tang and Ben Zhong Tang.

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Yang, J., Wei, J., Luo, F. et al. Enzyme-Responsive Peptide-Based AIE Bioprobes. Top Curr Chem (Z) 378, 47 (2020). https://doi.org/10.1007/s41061-020-00311-9

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