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Synthesis and Biological Evaluation of the Toxicity of Grafted 2-Mercaptobenzimidazole Multi-Walled Carbon Nanotubes (MWCNTs)

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Abstract

This work presents chemical functionalization of multi-walled carbon nanotubes (MWCNTs) through chemical modifications. Antibacterial conjugated MWCNTs were synthesized involving the sequential steps of carboxylation. Formation of the active intermediates using hydroxybenzotriazole (HOBt) was done in order to achieve conjugated 2-mercaptobenzimidazole (MWCNT-h) as the final compound. The modification of MWCNTs with antibacterial drug was checked by Fourier transform infrared spectroscopy, Raman spectroscopy, and thermogravimetric analysis. Size and surface characteristics of chemically modified MWCNTs were monitored by scanning electron microscopy and atomic force microscope. Minimal inhibitory concentration (MIC) and antimicrobial activity of functionalized and carboxyl MWCNTs were studied on two gram-negative bacteria as well as one gram-positive bacteria. The MIC results show that functionalized MWCNTs with antibacterial drugs have more effective results than single drug and carboxyl MWCNTs individually against all studied bacteria.

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Authors and Affiliations

  1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Moazzen Blvd., Rajaeeshahr, P.O. Box 31485-498, Karaj, Iran

    Yousef Fazaeli

  2. Faculty of Chemistry, Kashan University, Kashan, Iran

    Mohammadreza Gholibeikian

Authors
  1. Yousef Fazaeli
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  2. Mohammadreza Gholibeikian
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Correspondence to Yousef Fazaeli.

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Fazaeli, Y., Gholibeikian, M. Synthesis and Biological Evaluation of the Toxicity of Grafted 2-Mercaptobenzimidazole Multi-Walled Carbon Nanotubes (MWCNTs). Iran J Sci Technol Trans Sci 41, 145–150 (2017). https://doi.org/10.1007/s40995-017-0197-x

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  • DOI: https://doi.org/10.1007/s40995-017-0197-x

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