Abstract
Background
Uterine corpus tumors are one of the most common reasons for morbidity and mortality of women around the world, and histopathological diagnosis is the key for better management of the patients.
Aims
To study the histopathology of uterine tumors, classify them as per WHO 2014 classification and correlate with clinical parameters.
Methods
A five-year study was conducted on 433 histopathologically diagnosed cases of uterine corpus tumors.
Results
Benign tumors were the most common (95.6%) followed by malignant (3.9%) and borderline (0.5%). Leiomyoma was the most common benign tumor (91.2%). Majority of the cases were multiparous females (88.6%) in fourth and fifth decades of life (77%) and presenting with heavy menstrual bleeding (35.9%). The most location was intramural (68.9%). Cellular leiomyoma (1.8%) was the most common histologic variant; the secondary change was hyalinization (27.8%). Endometrial carcinoma was the most common malignant tumor (3%) followed by leiomyosarcoma (0.5%) and adenosarcoma (0.2%). Majority of the women with endometrial carcinoma were multiparous (76.9%) and belonging to the age-group of 50–59 years (38.4%). The most common symptom was postmenopausal bleeding (76.9%). Endometrioid carcinoma grade I (75%) was the most common type of endometrial carcinoma. Other lesions were adenomyoma (N = 17), STUMP (N = 2), and one case each of adenomatoid tumor, endometrial stromal nodule and secondary tumor.
Conclusion
Benign tumors were more common than malignant tumors. Leiomyoma was the most common benign tumor, and endometrial carcinoma was the most common malignant tumor. Many uterine tumors present with similar clinical features. However, histopathology plays an important role in the accurate diagnosis of different types of tumors and thus helps in providing the patient with appropriate management.
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Shetty, D.S., Gosavi, A.V., Murarkar, P.S. et al. Clinicopathological Correlation of Uterine Corpus Tumors: A Study of 433 Cases. Indian J Gynecol Oncolog 17, 71 (2019). https://doi.org/10.1007/s40944-019-0315-0
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DOI: https://doi.org/10.1007/s40944-019-0315-0