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The Big Black Brain: Subdural Hemorrhage with Hemispheric Swelling and Low Attenuation

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Abstract

The term “Big Black Brain” was first coined in 1993 to describe cases of abusive head trauma associated with subdural hematoma(s), brain swelling, and uni- or bilateral hypo-density involving the entire supratentorial compartment on CT scan imaging. This constellation of findings was invariably followed by extensive cerebral parenchymal destruction and a dismal neurological outcome or death. We describe two such cases and review the pathophysiology and differential diagnosis of this entity.

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References

  • Adelson, P. D., Ragheb, J., Kanev, P., Brockmeyer, D., Beers, S. R., Brown, S. D., & Levin, H. (2005). Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery, 56(4), 740–754. discussion 740-754.

    Article  PubMed  Google Scholar 

  • Barlow, K., Thompson, E., Johnson, D., & Minns, R. A. (2004). The neurological outcome of non-accidental head injury. Pediatric Rehabilitation, 7(3), 195–203. doi:10.1080/13638490410001715331.

    Article  PubMed  Google Scholar 

  • Bird, C. R., McMahan, J. R., Gilles, F. H., Senac, M. O., & Apthorp, J. S. (1987). Strangulation in child abuse: CT diagnosis. Radiology, 163(2), 373–375. doi:10.1148/radiology.163.2.3562816.

    Article  PubMed  Google Scholar 

  • Cantu, R. C. (2016). Dysautoregulation/Second impact syndrome with recurrent athletic head injury. World Neurosurgery. doi:10.1016/j.wneu.2016.04.056.

    PubMed  Google Scholar 

  • Cantu, R. C., & Gean, A. D. (2010). Second-impact syndrome and a small subdural hematoma: an uncommon catastrophic result of repetitive head injury with a characteristic imaging appearance. Journal of Neurotrauma, 27(9), 1557–1564. doi:10.1089/neu.2010.1334.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carré, M. (2006). Neuroradiology. In K. Rauth-Farley, L. Frasier, R. Alexander, & R. Parrish (Eds.), Abusive head trauma in infants and children: A medical, legal, and forensic reference (pp. 73–98). St. Louis: GW Publishing.

  • Case, M. E. (2008). Inflicted traumatic brain injury in infants and young children. Brain Pathology, 18(4), 571–582. doi:10.1111/j.1750-3639.2008.00204.x.

    Article  PubMed  Google Scholar 

  • Dias, M. S., Backstrom, J., Falk, M., & Li, V. (1998). Serial radiography in the infant shaken impact syndrome. Pediatric Neurosurgery, 29(2), 77–85.

    Article  PubMed  Google Scholar 

  • Donkin, J. J., Nimmo, A. J., Cernak, I., Blumbergs, P. C., & Vink, R. (2009). Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism, 29(8), 1388–1398. doi:10.1038/jcbfm.2009.63.

    Article  PubMed  Google Scholar 

  • Duhaime, A. C., Bilaniuk, L., & Zimmerman, R. (1993). The “big black brain”: radiographic changes after severe inflicted head injury in infancy. Journal of Neurotrauma, 10, S59.

    Google Scholar 

  • Duhaime, A. C., & Durham, S. (2007). Traumatic brain injury in infants: the phenomenon of subdural hemorrhage with hemispheric hypodensity (“Big Black Brain”). Progress in Brain Research, 161, 293–302. doi:10.1016/S0079-6123(06)61020-0.

    Article  PubMed  Google Scholar 

  • Figaji, A. A., Fieggen, A. G., Argent, A. C., Le Roux, P. D., & Peter, J. C. (2008). Intracranial pressure and cerebral oxygenation changes after decompressive craniectomy in children with severe traumatic brain injury. Acta Neurochirurgica Supplement, 102, 77–80.

    Article  PubMed  Google Scholar 

  • Gilles, E. E., & Nelson, M. D., Jr. (1998). Cerebral complications of nonaccidental head injury in childhood. Pediatric Neurology, 19(2), 119–128.

    Article  PubMed  Google Scholar 

  • Goldstein, J. L., Leonhardt, D., Kmytyuk, N., Kim, F., Wang, D., & Wainwright, M. S. (2011). Abnormal neuroimaging is associated with early in-hospital seizures in pediatric abusive head trauma. Neurocritical Care, 15(1), 63–69.

    Article  PubMed  Google Scholar 

  • Grant, P. (2015). Abusive head trauma: parenchymal injury. In P. Kleinman (Ed.), Diagnostic imaging of child abuse. Cambridge UK: Cambridge University Press.

    Google Scholar 

  • Graupman, P., & Winston, K. R. (2006). Nonaccidental head trauma as a cause of childhood death. Journal of Neurosurgery, 104(4 Suppl), 245–250.

    PubMed  Google Scholar 

  • Huh, J. W., & Raghupathi, R. (2009). New concepts in treatment of pediatric traumatic brain injury. Anesthesiology Clinics, 27(2), 213–240.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ichord, R. N., Naim, M., Pollock, A. N., Nance, M. L., Margulies, S. S., & Christian, C. W. (2007). Hypoxic-ischemic injury complicates inflicted and accidental traumatic brain injury in young children: the role of diffusion-weighted imaging. Journal of Neurotrauma, 24(1), 106–118.

    Article  PubMed  Google Scholar 

  • Kemp, A. M., Jaspan, T., Griffiths, J., Stoodley, N., Mann, M. K., Tempest, V., & Maguire, S. A. (2011). Neuroimaging: what neuroradiological features distinguish abusive from non-abusive head trauma? A systematic review. Archives of Disease in Childhood, 96(12), 1103–1112.

    Article  PubMed  Google Scholar 

  • Kemp, A. M., Stoodley, N., Cobley, C., Coles, L., & Kemp, K. W. (2003). Apnoea and brain swelling in non-accidental head injury. Archives of Disease in Childhood, 88(6), 472–476. discussion 472-476.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kuroda, Y., & Bullock, R. (1992). Local cerebral blood flow mapping before and after removal of acute subdural hematoma in the rat. Neurosurgery, 30(5), 687–691.

    PubMed  Google Scholar 

  • Liesemer, K., Bratton, S. L., Zebrack, C. M., Brockmeyer, D., & Statler, K. D. (2011). Early post-traumatic seizures in moderate to severe pediatric traumatic brain injury: rates, risk factors, and clinical features. Journal of Neurotrauma, 28(5), 755–762.

    Article  PubMed  Google Scholar 

  • Maguire, S., Pickerd, N., Farewell, D., Mann, M., Tempest, V., & Kemp, A. M. (2009). Which clinical features distinguish inflicted from non-inflicted brain injury? A systematic review. Archives of Disease in Childhood, 94(11), 860–867. doi:10.1136/adc.2008.150110.

    Article  PubMed  Google Scholar 

  • Marmarou, A. (2007). A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurgical Focus, 22(5), E1.

    Article  Google Scholar 

  • McKinney, A. M., Thompson, L. R., Truwit, C. L., Velders, S., Karagulle, A., & Kiragu, A. (2008). Unilateral hypoxic-ischemic injury in young children from abusive head trauma, lacking craniocervical vascular dissection or cord injury. Pediatric Radiology, 38(2), 164–174. doi:10.1007/s00247-007-0673-0.

    Article  PubMed  Google Scholar 

  • McLendon, L. A., Kralik, S. F., Grayson, P. A., & Golomb, M. R. (2016). The controversial second impact syndrome: a review of the literature. Pediatric Neurology, 62, 9–17. doi:10.1016/j.pediatrneurol.2016.03.009.

    Article  PubMed  Google Scholar 

  • Oehmichen, M., Schleiss, D., Pedal, I., Saternus, K. S., Gerling, I., & Meissner, C. (2008). Shaken baby syndrome: re-examination of diffuse axonal injury as cause of death. Acta Neuropathologica, 116(3), 317–329. doi:10.1007/s00401-008-0356-4.

    Article  PubMed  Google Scholar 

  • Parizel, P. M., Ceulemans, B., Laridon, A., Ozsarlak, O., Van Goethem, J. W., & Jorens, P. G. (2003). Cortical hypoxic-ischemic brain damage in shaken-baby (shaken impact) syndrome: value of diffusion-weighted MRI. Pediatric Radiology, 33(12), 868–871. doi:10.1007/s00247-003-1025-3.

    Article  PubMed  Google Scholar 

  • Peiniger, S., Nienaber, U., Lefering, R., Braun, M., & Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. (2012). Glasgow coma scale as a predictor for hemocoagulative disorders after blunt pediatric traumatic brain injury. Pediatr Crit Care Med, 13(4), 455–460. doi:10.1097/PCC.0b013e31823893c5.

  • Scholefield, B., Duncan, H., Davies, P., Gao Smith, F., Khan, K., Perkins, G. D., & Morris, K. (2013). Hypothermia for neuroprotection in children after cardiopulmonary arrest. Cochrane Database of Systematic Reviews, 2, CD009442. doi:10.1002/14651858.CD009442.pub2.

    Google Scholar 

  • Squier, W., Mack, J., Green, A., & Aziz, T. (2012). The pathophysiology of brain swelling associated with subdural hemorrhage: the role of the trigeminovascular system. Childs Nervous System, 28(12), 2005–2015. doi:10.1007/s00381-012-1870-1.

    Article  Google Scholar 

  • Stam, A. H., Luijckx, G. J., Poll-The, B. T., Ginjaar, I. B., Frants, R. R., Haan, J., & van den Maagdenberg, A. M. (2009). Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation. Journal of Neurology, Neurosurgery, and Psychiatry, 80(10), 1125–1129. doi:10.1136/jnnp.2009.177279.

    Article  PubMed  Google Scholar 

  • Tantsis, E. M., Gill, D., Griffiths, L., Gupta, S., Lawson, J., Maksemous, N., & Menezes, M. P. (2016). Eye movement disorders are an early manifestation of CACNA1A mutations in children. Developmental Medicine and Child Neurology, 58(6), 639–644. doi:10.1111/dmcn.13033.

    Article  PubMed  Google Scholar 

  • Topal, N. B., Hakyemez, B., Erdogan, C., Bulut, M., Koksal, O., Akkose, S., & Korfali, E. (2008). MR imaging in the detection of diffuse axonal injury with mild traumatic brain injury. Neurological Research, 30(9), 974–978. doi:10.1179/016164108X323799.

    Article  PubMed  Google Scholar 

  • Weinstein, E., Turner, M., Kuzma, B. B., & Feuer, H. (2013). Second impact syndrome in football: new imaging and insights into a rare and devastating condition. Journal of Neurosurgery Pediatrics, 11(3), 331–334. doi:10.3171/2012.11.PEDS12343.

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors would like to thank Kara G. Gill, MD for contributing radiologic imaging to this manuscript.

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Correspondence to Barbara L. Knox.

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Disclosure of Interest

Drs. Knox and Feldman both testify in civil and criminal trials. Monies earned are given to their respective institutions and to Dr. Feldman. Drs. Knox and Luyet are currently authoring a book on child torture as a form of child abuse.

Ethical Standards and Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation [institutional and national] and with the Helsinki Declaration of 1975, as revised in 2000. This manuscript discusses two cases of children with big black brain presentations. Both the University of Wisconsin Health Sciences IRB and the University of Washington IRB did not require IRB approval for these case reports. Additionally, no informed consent of patients was required.

Additional information

Drs. Knox and Feldman both testify in civil and criminal trials. Monies are given to their respective institutions and to Dr. Feldman. Drs. Knox and Luyet are currently writing a book on child torture as a form of child abuse.

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Luyet, F.M., Feldman, K.W. & Knox, B.L. The Big Black Brain: Subdural Hemorrhage with Hemispheric Swelling and Low Attenuation. Journ Child Adol Trauma 11, 241–247 (2018). https://doi.org/10.1007/s40653-017-0132-5

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