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Acute renal infarction: long-term renal outcome and prognostic factors

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Abstract

Introduction

Acute renal infarction is a rare occurence, whose  prognosis and long-term outcomes remain poorly studied. This study evaluated whether clinical and radiological features at diagnosis can be associated with the long-term outcomes (blood pressure, kidney function and mortality).

Methods

We retrospectively analyzed the demographic, clinical, biological and radiological data of patients with acute renal infarction hospitalized at Rennes University Hospital between 1997 and 2017 (n = 94).

Results

Patients were followed-up for a median of 60 months. At time of diagnosis of acute renal infarction median age was 53 years, 45% of the patients had acute hypertension, and 31% had Acute Kidney Injury (AKI) requiring dialysis in seven patients. The median Lactate DeHydrogenase (LDH) level was 977 IU/mL. The median extent of kidney damage was 14%, with left renal involvement in 51% of patients. At 60 months of follow-up, 66% of patients had developed Chronic Kidney Disease (CKD) stage 3 or higher, and 55% had hypertension since diagnosis. Age, acute development of hypertension and AKI at diagnosis were associated with long-term CKD (stage 3 or higher) in multivariate analyses, but the extent of kidney damage was not. During the follow-up, 21% of patients died, and only age resulted as a predisposing factor. No tested factor was correlated with long-term hypertension.

Discussion

Age, acute development of hypertension, and AKI were correlated with long term CKD, whereas no factor was correlated with long-term hypertension after acute renal infarction.

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References

  1. Lessman RK (1978) Renal artery embolism: clinical features and long-term follow-up of 17 cases. Ann Intern Med 89(4):477

    Article  CAS  Google Scholar 

  2. Antopolsky M, Simanovsky N, Stalnikowicz R, Salameh S, Hiller N (2012) Renal infarction in the ED: 10-year experience and review of the literature. Am J Emerg Med 30(7):1055–1060

    Article  Google Scholar 

  3. Nagasawa T, Matsuda K, Takeuchi Y, Fukami H, Sato H, Saito A et al (2016) A case series of acute renal infarction at a single center in Japan. Clin Exp Nephrol 20(3):411–415

    Article  Google Scholar 

  4. Domanovits H, Paulis M, Nikfardjam M, Meron G, Kürkciyan I, Bankier AA et al (1999) Acute renal infarction: clinical characteristics of 17 patients. Medicine 78(6):386–394

    Article  CAS  Google Scholar 

  5. Huang C-C, Lo H-C, Huang H-H, Kao W-F, Yen DH-T, Wang L-M et al (2007) ED presentations of acute renal infarction. Am J Emerg Med 25(2):164–169

    Article  Google Scholar 

  6. Mesiano P, Rollino C, Beltrame C, Ferro M, Rocatello D et al (2017) Acute renal infarction: a single center experience. J Nephrol 30(1):103–107

    Article  Google Scholar 

  7. Faucon A-L, Bobrie G, Jannot A-S, Azarine A, Plouin P-F, Azizi M et al (2018) Cause of renal infarction: a retrospective analysis of 186 consecutive cases. J Hypertens 36(3):634–640

    Article  CAS  Google Scholar 

  8. Bourgault M, Grimbert P, Verret C, Pourrat J, Herody M, Halimi JM et al (2013) Acute renal infarction: a case series. Clin J Am Soc Nephrol 8(3):392–398

    Article  Google Scholar 

  9. Bae EJ, Hwang K, Jang HN, Kim MJ, Jeon D-H, Kim H-J et al (2014) A retrospective study of short- and long-term effects on renal function after acute renal infarction. Ren Fail 36(9):1385–1389

    Article  CAS  Google Scholar 

  10. Oh YK, Yang CW, Kim Y-L, Kang S-W, Park CW, Kim YS et al (2016) Clinical characteristics and outcomes of renal infarction. Am J Kidney Dis 67(2):243–250

    Article  Google Scholar 

  11. Ongun S, Bozkurt O, Demir O, Cimen S, Aslan G (2015) Midterm renal functions following acute renal infarction. Kaohsiung J Med Sci 31(10):529–533

    Article  Google Scholar 

  12. Iqbal FM, Goparaju M, Yemme S, Lewis BE (2009) Renal artery dissection following marathon running. Angiology 60(1):122–126

    Article  Google Scholar 

  13. Sinnamon K, McNally D, Harty J (2007) Fibromuscular dysplasia presenting as renal infarction. Kidney Int 72(10):1295–1296

    Article  CAS  Google Scholar 

  14. Hazanov N, Somin M, Attali M, Beilinson N, Thaler M, Mouallem M et al (2004) Acute renal embolism: forty-four cases of renal infarction in patients with atrial fibrillation. Medicine 83(5):292–299

    Article  Google Scholar 

  15. Bienaimé F, Legendre C, Terzi F, Canaud G (2017) Antiphospholipid syndrome and kidney disease. Kidney Int 91(1):34–44

    Article  Google Scholar 

  16. Eren N, Gungor O, Guzel FB, Erken E, Altunoren O, Tatar E et al (2018) Acute renal infarction in Turkey : a review of 121 cases. Int Urol Nephrol 50(11):2067–2072

    Article  Google Scholar 

  17. Levey A, Bosch J, Lewis J, Greene T, Rogers T, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130(6):461–470

    Article  CAS  Google Scholar 

  18. Kidney DIsease : Improving Global Outcome (KDIGO) (2012) Acute Kidney Injury Work Group KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2(Suppl 1):1–138

    Google Scholar 

  19. Kidney DIsease : Improving Global Outcome (KDIGO) (2013) Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3(1):1–163

    Article  Google Scholar 

  20. Ardalan M, Nasri H, Ghabili K, Mohajel Shoja M. Acute tubular necrosis after renal allograft segmental infarction : the nephrotoxicity of necrotic material. Exp Clin Transplant. 6(4):312–4.

  21. Rosenberger C, Griethe W, Gruber G, Wiesener M, Frei U, Bachmann S et al (2003) Cellular responses to hypoxia after renal segmental infarction. Kidney Int 64(3):874–886

    Article  Google Scholar 

  22. Norman R, Galloway P, Dzielak D, Huang M (1988) Mechanisms of partial renal infarct hypertension. J Hypertens 6:397–403

    Article  Google Scholar 

  23. Loomis D (1946) Hypertension and necrotizing arteritis in the rat following renal infarction. Arch Pathol 41:231–268

    CAS  Google Scholar 

  24. Sokabe H, Grollman A (1963) A study of hypertension in the rat induced by infarction of the kidney. Tex Rep Biol Med 21:93–100

    CAS  PubMed  Google Scholar 

  25. White F, Grollman A (1964) Autoimmune factors associated with infarction of the kidney. Nephron 1:93–102

    Article  CAS  Google Scholar 

  26. Svendsen U (1977) The importance of thymus in the pathogenesis of the chronic phase of hypertension in mice following partial infarction of the kidney. Acta Pathol Microbiol Scand 85(A):539–547

    CAS  Google Scholar 

  27. Paris B, Bobrie G, Rossignol P, Le Coz S, Chedid A, Plouin P-F (2006) Blood pressure and renal outcomes in patients with kidney infarction and hypertension. J Hypertens 24(8):1649–1654

    Article  CAS  Google Scholar 

  28. Reboldi G, Gentile G, Angeli F, Verdecchia P (2018) The 2018 ESC/ESH hypertension guidelines: should nephrologists always stop at the lower boundary? J Nephrol 31:621–626

    Article  Google Scholar 

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Funding

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Author information

Author notes

  1. Arnaud Delezire and Marianne Terrasse equal participation in the work.

Authors and Affiliations

  1. Service de Néphrologie, CHU Hôpital Pontchaillou, 2 rue Henri Le Guilloux, 35033, Rennes Cedex, France

    Arnaud Delezire, Marianne Terrasse & Cécile Vigneau

  2. Centre Hospitalier Public du Cotentin, Service de Néphrologie, Rue Trottebec, BP 208, 50102, Cherbourg Octeville Cedex, France

    Julien Bouet

  3. CHU Hôpital Pontchaillou, Service d’Imagerie médicale, 2 rue Henri Le Guilloux, 35033, Rennes Cedex, France

    Maxence Laot & Vanessa Brun

  4. Faculté de Médecine, Université Rennes 1, Équipe de Pharmacoépidémiologie, INSERM CIC 0203, 2 avenue du Professeur Léon Bernard, CS 34317, 35043, Rennes Cedex, France

    Emmanuel Oger

  5. Centre Régional de Pharmacovigilance, CHU Hôpital Pontchaillou, 2 rue Henri Le Guilloux, 35033, Rennes Cedex, France

    Emmanuel Oger

  6. Université Rennes 1, INSERM, U1085 IRSET-9, 35033, Rennes, France

    Cécile Vigneau

Authors
  1. Arnaud Delezire
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  2. Marianne Terrasse
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  3. Julien Bouet
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  4. Maxence Laot
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  5. Vanessa Brun
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  6. Emmanuel Oger
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  7. Cécile Vigneau
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All authors read and approved the final manuscript.

Corresponding author

Correspondence to Arnaud Delezire.

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The authors declare that they have no competing interests.

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Permission from the Rennes University Hospital ethics review committee was granted (permission n° 12–53 V. MOREL).

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The anonymous datasets used and analyzed for the current study are available from the corresponding author on reasonable request.

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Delezire, A., Terrasse, M., Bouet, J. et al. Acute renal infarction: long-term renal outcome and prognostic factors. J Nephrol 34, 1501–1509 (2021). https://doi.org/10.1007/s40620-020-00953-4

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  • DOI: https://doi.org/10.1007/s40620-020-00953-4

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