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Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management

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Abstract

Pregnancy-associated atypical hemolytic uremic syndrome is a systemic disease associated with high morbidity and mortality rates, caused by dysregulation of the alternative complement pathway, leading to uncontrolled complement activation resulting in thrombotic microangiopathy. This condition can be effectively treated by anti-C5 therapy, which controls complement activation. Treatment can be safely discontinued after complete remission and resolution of the precipitating cause, especially in patients with a low-risk genetic profile.

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Conflict of interest

Dr. E. De Sousa acts as a scientific advisor for Alexion Pharmaceuticals. Dr. Campistol, Dr. Rodriguez de Cordoba and Mr. Blasco have received fees from Alexion Pharmaceuticals for invited lectures. The other authors declare that they have no relevant conflicts of interest.

Ethical standard

The present study was performed in accordance with the ethical standards of the institutional research committee and with the Helsinki declaration.

Informed consent

Written consent was obtained from the patient discussed and documentation is available for review upon request.

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Authors and Affiliations

  1. Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain

    Erika De Sousa Amorim, Miquel Blasco, Luis Quintana & Josep Maria Campistol

  2. Histopathology Department, Hospital Clinic, Barcelona, Spain

    Manel Sole

  3. Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040, Madrid, Spain

    Santiago Rodríguez de Cordoba

Authors
  1. Erika De Sousa Amorim
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  2. Miquel Blasco
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  3. Luis Quintana
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  4. Manel Sole
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  5. Santiago Rodríguez de Cordoba
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  6. Josep Maria Campistol
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Corresponding author

Correspondence to Erika De Sousa Amorim.

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De Sousa Amorim, E., Blasco, M., Quintana, L. et al. Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management. J Nephrol 28, 641–645 (2015). https://doi.org/10.1007/s40620-015-0173-5

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  • DOI: https://doi.org/10.1007/s40620-015-0173-5

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