Abstract
Background
Previously published data on the association between the XRCC1 Arg194Trp polymorphism and thyroid cancer (TC) remain controversial.
Methods
To clarify the association between the XRCC1 Arg194Trp polymorphism and susceptibility to TC, a meta-analysis of case–control studies was conducted. We systematically searched PubMed and CNKI to identify relevant studies. Pooled odds ratios (ORs) of various genetic models were estimated using fixed and random effects models. Heterogeneity was detected by Q-statistic, and the Egger’s test was used to evaluate the publication bias.
Results
A total of seven eligible studies for the XRCC1 Arg194Trp polymorphism (1500 patients and 2358 controls) were included in this meta-analysis. The results of our study failed to suggest an association between the Arg194Trp polymorphism and susceptibility of TC. However, in the subgroup analyses by ethnicity, the OR was 0.82 (C allele vs. T allele, 95% CI 0.68–0.98; P = 0.24 for heterogeneity) among the Chinese population. Nevertheless, no significant differences were observed in the Caucasian population in any genetic model.
Conclusion
This study suggested that the C allele of XRCC1 had an 18% significantly decreased risk of TC in Chinese, and there were no significant associations among Caucasians under all genetic models.
Similar content being viewed by others
References
Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: gLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
Ramón Y, Cajal S, Capdevila C, Hernandez-Losa J et al (1868) Cancer as an ecomolecular disease and a neoplastic consortium. Biochim Biophys Acta Rev Cancer 2:484–499
Zidane M, Cazier JB, Chevillard S et al (2019) Genetic susceptibility to radiation-related thyroid cancer: a systematic review. Endocr Relat Cancer. https://doi.org/10.1530/ERC-19-0321
Wood RD, Mitchell M, Sgouros J, Lindahl T (2001) Human DNA repair genes. Science 291(5507):1284–1289
Çağlayan M, Wilson SH (2015) Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst) 35:85–89
Chang-Claude J, Popanda O, Tan XL et al (2005) Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res 11(13):4802–4809
Zhao JZ, Tan XR, Zhao M, Mao XC, Jiang L (2016) Association between the X-ray repair cross-complementing group 1 Arg194Trp polymorphism and thyroid carcinoma susceptibility: a meta-analysis. Genet Mol Res. https://doi.org/10.4238/gmr.15037793
Bao Y, Jiang L, Zhou JY et al (2013) XRCC1 gene polymorphisms and the risk of differentiated thyroid carcinoma (DTC): a meta-analysis of case-control studies. PLoS One 8(5):e64851
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129
Egger M, Davey Smith G, Schneider M et al (1997) Bias in metaanalysis detected by a simple, graphical test. BMJ 315:629–634
Bashir K, Sarwar R, Fatima S et al (2018) Haplotype analysis of XRCC1 gene polymorphisms and the risk of thyroid carcinoma. J BUON 23(1):234–243
Wang X, Zhang K, Liu X, Liu B, Wang Z (2015) Association between XRCC1 and XRCC3 gene polymorphisms and risk of thyroid cancer. Int J Clin Exp Pathol 8(3):3160–3167
Siraj AK, Al-Rasheed M, Ibrahim M et al (2008) RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population. J Endocrinol Invest 31(10):893–899
Chiang FY, Wu CW, Hsiao PJ et al (2008) Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma. Clin Cancer Res 14(18):5919–5924
Fard-Esfahani P, Fard-Esfahani A, Fayaz S et al (2011) Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. Iran Biomed J 15(3):73–78
Halkova T, Dvorakova S, Sykorova V et al (2016) Polymorphisms in selected DNA repair genes and cell cycle regulating genes involved in the risk of papillary thyroid carcinoma. Cancer Biomark 17(1):97–106
Ho T, Li G, Lu J, Zhao C, Wei Q, Sturgis EM (2009) Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis. Thyroid 19(2):129–135
Ryu RA, Tae K, Min HJ et al (2011) XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample. J Korean Med Sci 26(8):991–995
Santos LS, Branco SC, Silva SN et al (2012) Polymorphisms in base excision repair genes and thyroid cancer risk. Oncol Rep 28(5):1859–1868
Yan L, Li Q, Li X, Ji H, Zhang L (2016) Association studies between XRCC1, XRCC2, XRCC3 polymorphisms and differentiated thyroid carcinoma. Cell Physiol Biochem 38(3):1075–1084
Zhu QX, Bian JC, Shen Q et al (2004) Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma. Zhonghua Liu Xing Bing Xue Za Zhi 25:702–705
Marintchev A, Mullen MA, Maciejewski MW, Pan B, Gryk MR, Mullen GP (1999) Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nat Struct Biol 6(9):884–893
Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45–61
Bushnik T, Evans WK (2018) Sociodemographic characteristics associated with thyroid cancer risk in Canada. Health Rep 29(10):3–11
Sigurdson AJ, Land CE, Bhatti P et al (2009) Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan. Radiat Res 171(1):77–88
Funding
None.
Author information
Authors and Affiliations
Contributions
All authors participated in the study. LSY and XW performed the literature search and the extraction of data. LSY performed the data analysis. LSY and XW participated in the interpretation of data and the writing of the manuscript. XW revised the article for important intellectual content. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed consent
For this type of study formal consent is not required.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Liu, SY., Xue, W. XRCC1 Arg194Trp polymorphism and thyroid cancer. J Endocrinol Invest 43, 749–753 (2020). https://doi.org/10.1007/s40618-019-01155-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40618-019-01155-x